Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4706_RS02945 Genome accession   NZ_CP137111
Coordinates   592204..592941 (-) Length   245 a.a.
NCBI ID   WP_001219120.1    Uniprot ID   Q9S1I6
Organism   Streptococcus pneumoniae strain 17023     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 587204..597941
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4706_RS02920 blpA 587580..588848 (+) 1269 Protein_579 peptide cleavage/export ABC transporter BlpA -
  R4706_RS02925 comA/nlmT 589058..589222 (+) 165 WP_306420852.1 hypothetical protein Regulator
  R4706_RS02930 - 589233..590594 (+) 1362 WP_050233594.1 bacteriocin secretion accessory protein -
  R4706_RS02935 blpC 590651..590779 (+) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  R4706_RS02940 - 590850..592190 (-) 1341 WP_001017646.1 sensor histidine kinase -
  R4706_RS02945 comE/blpR 592204..592941 (-) 738 WP_001219120.1 LytTR family DNA-binding domain-containing protein Regulator
  R4706_RS02950 - 592946..593284 (-) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  R4706_RS02955 - 593560..593889 (+) 330 WP_000132572.1 hypothetical protein -
  R4706_RS02960 - 594057..595106 (-) 1050 WP_044727698.1 ABC transporter permease -
  R4706_RS02965 pptA 595103..595834 (-) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  R4706_RS02970 - 595902..596312 (+) 411 WP_001278301.1 HIT family protein -
  R4706_RS02975 - 596322..596609 (+) 288 WP_000777760.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28754.98 Da        Isoelectric Point: 6.5884

>NTDB_id=895928 R4706_RS02945 WP_001219120.1 592204..592941(-) (comE/blpR) [Streptococcus pneumoniae strain 17023]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895928 R4706_RS02945 WP_001219120.1 592204..592941(-) (comE/blpR) [Streptococcus pneumoniae strain 17023]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1I6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376
  comE Streptococcus infantis strain Atu-4

35.887

100

0.363