Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4704_RS08205 Genome accession   NZ_CP137109
Coordinates   1572263..1573000 (+) Length   245 a.a.
NCBI ID   WP_001219122.1    Uniprot ID   A0A0I5XJR5
Organism   Streptococcus pneumoniae strain 11012     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1567263..1578000
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4704_RS08170 - 1568238..1568432 (-) 195 WP_001808905.1 hypothetical protein -
  R4704_RS08175 - 1568594..1568881 (-) 288 WP_000777753.1 hypothetical protein -
  R4704_RS08180 - 1568891..1569301 (-) 411 WP_001278301.1 HIT family protein -
  R4704_RS08185 pptA 1569369..1570100 (+) 732 WP_000889921.1 ABC transporter ATP-binding protein Regulator
  R4704_RS08190 - 1570097..1571146 (+) 1050 WP_000653771.1 ABC transporter permease -
  R4704_RS08195 - 1571314..1571643 (-) 330 WP_000132572.1 hypothetical protein -
  R4704_RS08200 - 1571920..1572258 (+) 339 WP_000682133.1 LytTR family DNA-binding domain-containing protein -
  R4704_RS08205 comE/blpR 1572263..1573000 (+) 738 WP_001219122.1 LytTR family DNA-binding domain-containing protein Regulator
  R4704_RS08210 - 1573013..1574353 (+) 1341 WP_000275285.1 sensor histidine kinase -
  R4704_RS08215 blpC 1574398..1574553 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  R4704_RS08220 - 1574610..1575971 (-) 1362 WP_033705510.1 bacteriocin secretion accessory protein -
  R4704_RS08225 comA/nlmT 1575982..1577658 (-) 1677 WP_317830619.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28766.95 Da        Isoelectric Point: 6.4140

>NTDB_id=895821 R4704_RS08205 WP_001219122.1 1572263..1573000(+) (comE/blpR) [Streptococcus pneumoniae strain 11012]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895821 R4704_RS08205 WP_001219122.1 1572263..1573000(+) (comE/blpR) [Streptococcus pneumoniae strain 11012]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0I5XJR5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38