Detailed information
Bioinformatically predicted
Overview
| Name | cclA/cilC | Type | Machinery gene |
| Locus tag | R4711_RS07870 | Genome accession | NZ_CP137107 |
| Coordinates | 1525828..1526487 (-) | Length | 219 a.a. |
| NCBI ID | WP_000565010.1 | Uniprot ID | A0A0B7M2C6 |
| Organism | Streptococcus pneumoniae strain 15H4024 | ||
| Function | processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
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Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 1527231..1557170 | 1525828..1526487 | flank | 744 |
Gene organization within MGE regions
Location: 1525828..1557170
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| R4711_RS07870 | cclA/cilC | 1525828..1526487 (-) | 660 | WP_000565010.1 | A24 family peptidase | Machinery gene |
| R4711_RS07875 | - | 1526557..1526955 (+) | 399 | WP_000155403.1 | N-acetyltransferase | - |
| R4711_RS07880 | - | 1527231..1528409 (-) | 1179 | WP_000175876.1 | ROK family transcriptional regulator | - |
| R4711_RS07885 | - | 1528689..1529951 (+) | 1263 | WP_000413336.1 | PTS sugar transporter subunit IIC | - |
| R4711_RS07890 | - | 1529954..1530850 (+) | 897 | WP_000825669.1 | PEP phosphonomutase | - |
| R4711_RS07895 | - | 1530865..1531182 (+) | 318 | WP_001151646.1 | PTS sugar transporter subunit IIB | - |
| R4711_RS07900 | - | 1531199..1531516 (+) | 318 | WP_001005881.1 | PTS lactose/cellobiose transporter subunit IIA | - |
| R4711_RS07905 | - | 1531526..1532881 (+) | 1356 | WP_001094994.1 | PTS sugar transporter subunit IIC | - |
| R4711_RS07910 | - | 1533204..1534679 (+) | 1476 | WP_000250870.1 | arylsulfatase | - |
| R4711_RS07915 | - | 1534676..1535524 (+) | 849 | WP_000782429.1 | formylglycine-generating enzyme family protein | - |
| R4711_RS07920 | - | 1535539..1536309 (+) | 771 | WP_000229328.1 | sulfite exporter TauE/SafE family protein | - |
| R4711_RS07925 | - | 1536587..1536832 (-) | 246 | WP_001809004.1 | IS30 family transposase | - |
| R4711_RS07930 | - | 1537104..1537349 (+) | 246 | WP_255296894.1 | transposase | - |
| R4711_RS07935 | - | 1537459..1537662 (-) | 204 | WP_000109957.1 | CsbD family protein | - |
| R4711_RS07940 | - | 1537693..1538301 (-) | 609 | WP_000064115.1 | Asp23/Gls24 family envelope stress response protein | - |
| R4711_RS07945 | - | 1538340..1538510 (-) | 171 | WP_000455066.1 | DUF2273 domain-containing protein | - |
| R4711_RS07950 | amaP | 1538522..1539088 (-) | 567 | WP_000030213.1 | alkaline shock response membrane anchor protein AmaP | - |
| R4711_RS07955 | - | 1539172..1539336 (-) | 165 | WP_001809002.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
| R4711_RS07960 | mgaSpn | 1539779..1541260 (+) | 1482 | WP_001205280.1 | virulence factor transcriptional regulator MgaSpn | - |
| R4711_RS07965 | - | 1541622..1542617 (+) | 996 | WP_000230210.1 | LacI family DNA-binding transcriptional regulator | - |
| R4711_RS07970 | - | 1542744..1544054 (+) | 1311 | WP_171011131.1 | sugar ABC transporter substrate-binding protein | - |
| R4711_RS07975 | - | 1544150..1545052 (+) | 903 | WP_000032532.1 | carbohydrate ABC transporter permease | - |
| R4711_RS07980 | - | 1545054..1545899 (+) | 846 | WP_000819520.1 | carbohydrate ABC transporter permease | - |
| R4711_RS07985 | - | 1545909..1547228 (+) | 1320 | WP_050263892.1 | glycoside hydrolase family 32 protein | - |
| R4711_RS07995 | - | 1547775..1549046 (-) | 1272 | WP_001113218.1 | replication-associated recombination protein A | - |
| R4711_RS08000 | - | 1549316..1549555 (+) | 240 | WP_000818078.1 | hypothetical protein | - |
| R4711_RS08005 | - | 1549720..1549899 (+) | 180 | WP_001048906.1 | hypothetical protein | - |
| R4711_RS08010 | - | 1550036..1550215 (+) | 180 | WP_001132285.1 | type II toxin-antitoxin system HicA family toxin | - |
| R4711_RS08015 | - | 1550252..1550704 (+) | 453 | WP_000961810.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| R4711_RS08020 | - | 1550995..1551465 (+) | 471 | WP_000257084.1 | DUF3013 family protein | - |
| R4711_RS08025 | - | 1551484..1552551 (+) | 1068 | WP_000719723.1 | site-2 protease family protein | - |
| R4711_RS08030 | - | 1552553..1552702 (+) | 150 | Protein_1537 | 7,8-dihydro-8-oxoguanine-triphosphatase | - |
| R4711_RS08035 | - | 1552821..1553855 (+) | 1035 | WP_000747915.1 | ATP-binding protein | - |
| R4711_RS08040 | - | 1553917..1556100 (+) | 2184 | WP_000529017.1 | S8 family peptidase | - |
| R4711_RS08045 | - | 1556151..1557170 (+) | 1020 | WP_001028057.1 | AbiH family protein | - |
Sequence
Protein
Download Length: 219 a.a. Molecular weight: 24845.99 Da Isoelectric Point: 7.5762
>NTDB_id=895667 R4711_RS07870 WP_000565010.1 1525828..1526487(-) (cclA/cilC) [Streptococcus pneumoniae strain 15H4024]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV
Nucleotide
Download Length: 660 bp
>NTDB_id=895667 R4711_RS07870 WP_000565010.1 1525828..1526487(-) (cclA/cilC) [Streptococcus pneumoniae strain 15H4024]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| cclA/cilC | Streptococcus pneumoniae Rx1 |
100 |
100 |
1 |
| cclA/cilC | Streptococcus pneumoniae D39 |
100 |
100 |
1 |
| cclA/cilC | Streptococcus pneumoniae R6 |
100 |
100 |
1 |
| cclA/cilC | Streptococcus pneumoniae TIGR4 |
94.977 |
100 |
0.95 |
| cclA/cilC | Streptococcus mitis SK321 |
92.694 |
100 |
0.927 |
| cclA/cilC | Streptococcus mitis NCTC 12261 |
87.671 |
100 |
0.877 |