Detailed information
Bioinformatically predicted
Overview
| Name | cclA/cilC | Type | Machinery gene |
| Locus tag | R4702_RS07925 | Genome accession | NZ_CP137106 |
| Coordinates | 1527906..1528565 (-) | Length | 219 a.a. |
| NCBI ID | WP_000565017.1 | Uniprot ID | A0A0E8GKN8 |
| Organism | Streptococcus pneumoniae strain 16P4028 | ||
| Function | processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
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Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 1509799..1544697 | 1527906..1528565 | within | 0 |
Gene organization within MGE regions
Location: 1509799..1544697
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| R4702_RS07830 | - | 1509817..1510200 (+) | 384 | WP_001813172.1 | hypothetical protein | - |
| R4702_RS07835 | - | 1510258..1510899 (+) | 642 | WP_317809624.1 | phosphate uptake regulator PhoU | - |
| R4702_RS07840 | galT | 1510912..1512387 (+) | 1476 | WP_000848802.1 | UDP-glucose--hexose-1-phosphate uridylyltransferase | - |
| R4702_RS07845 | galE | 1512400..1513380 (+) | 981 | WP_317809626.1 | UDP-glucose 4-epimerase GalE | - |
| R4702_RS07850 | - | 1513590..1514249 (+) | 660 | WP_000793807.1 | DUF1868 domain-containing protein | - |
| R4702_RS07855 | - | 1514274..1515341 (+) | 1068 | WP_000738372.1 | extracellular solute-binding protein | - |
| R4702_RS07860 | - | 1515444..1516454 (+) | 1011 | WP_000589142.1 | ABC transporter ATP-binding protein | - |
| R4702_RS07865 | - | 1516466..1518157 (+) | 1692 | WP_001216185.1 | iron ABC transporter permease | - |
| R4702_RS07870 | - | 1518160..1518870 (+) | 711 | WP_000127552.1 | MgtC/SapB family protein | - |
| R4702_RS07875 | - | 1518966..1519334 (+) | 369 | WP_219590585.1 | hypothetical protein | - |
| R4702_RS07880 | - | 1519442..1520443 (+) | 1002 | WP_000789949.1 | LacI family DNA-binding transcriptional regulator | - |
| R4702_RS07885 | - | 1521051..1521302 (+) | 252 | WP_317809627.1 | hypothetical protein | - |
| R4702_RS07890 | trpE | 1521675..1523036 (+) | 1362 | WP_219590583.1 | anthranilate synthase component I | - |
| R4702_RS07895 | - | 1523033..1523599 (+) | 567 | WP_000601930.1 | aminodeoxychorismate/anthranilate synthase component II | - |
| R4702_RS07900 | trpD | 1523610..1524614 (+) | 1005 | WP_000658684.1 | anthranilate phosphoribosyltransferase | - |
| R4702_RS07905 | trpC | 1524611..1525378 (+) | 768 | WP_000076567.1 | indole-3-glycerol phosphate synthase TrpC | - |
| R4702_RS07910 | - | 1525365..1525964 (+) | 600 | WP_000169915.1 | phosphoribosylanthranilate isomerase | - |
| R4702_RS07915 | trpB | 1525942..1527165 (+) | 1224 | WP_000331287.1 | tryptophan synthase subunit beta | - |
| R4702_RS07920 | trpA | 1527158..1527934 (+) | 777 | WP_044788824.1 | tryptophan synthase subunit alpha | - |
| R4702_RS07925 | cclA/cilC | 1527906..1528565 (-) | 660 | WP_000565017.1 | A24 family peptidase | Machinery gene |
| R4702_RS07930 | - | 1528635..1529081 (+) | 447 | WP_000155429.1 | GNAT family N-acetyltransferase | - |
| R4702_RS07935 | - | 1529309..1530487 (-) | 1179 | WP_000175886.1 | ROK family transcriptional regulator | - |
| R4702_RS07940 | - | 1530767..1532029 (+) | 1263 | WP_000413336.1 | PTS sugar transporter subunit IIC | - |
| R4702_RS07945 | - | 1532032..1532928 (+) | 897 | WP_016398462.1 | hypothetical protein | - |
| R4702_RS07950 | - | 1532943..1533260 (+) | 318 | WP_001151646.1 | PTS sugar transporter subunit IIB | - |
| R4702_RS07955 | - | 1533277..1533594 (+) | 318 | WP_001005881.1 | PTS lactose/cellobiose transporter subunit IIA | - |
| R4702_RS07960 | - | 1533604..1534959 (+) | 1356 | WP_001094994.1 | PTS sugar transporter subunit IIC | - |
| R4702_RS07965 | - | 1535283..1536758 (+) | 1476 | WP_279513521.1 | arylsulfatase | - |
| R4702_RS07970 | - | 1536755..1537603 (+) | 849 | WP_279513522.1 | formylglycine-generating enzyme family protein | - |
| R4702_RS07975 | - | 1537618..1538388 (+) | 771 | WP_000229339.1 | sulfite exporter TauE/SafE family protein | - |
| R4702_RS07980 | - | 1538666..1538911 (-) | 246 | WP_001810496.1 | IS30 family transposase | - |
| R4702_RS07985 | - | 1539190..1539429 (+) | 240 | WP_001005784.1 | transposase | - |
| R4702_RS07990 | - | 1539539..1539742 (-) | 204 | WP_000109957.1 | CsbD family protein | - |
| R4702_RS07995 | - | 1539773..1540381 (-) | 609 | WP_000064115.1 | Asp23/Gls24 family envelope stress response protein | - |
| R4702_RS08000 | - | 1540420..1540590 (-) | 171 | WP_000455066.1 | DUF2273 domain-containing protein | - |
| R4702_RS08005 | amaP | 1540602..1541168 (-) | 567 | WP_000030213.1 | alkaline shock response membrane anchor protein AmaP | - |
| R4702_RS08010 | - | 1541252..1541416 (-) | 165 | WP_001809002.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
| R4702_RS08015 | mgaSpn | 1541859..1543340 (+) | 1482 | WP_001205276.1 | virulence factor transcriptional regulator MgaSpn | - |
| R4702_RS08020 | - | 1543702..1544697 (+) | 996 | WP_000230210.1 | LacI family DNA-binding transcriptional regulator | - |
Sequence
Protein
Download Length: 219 a.a. Molecular weight: 24879.99 Da Isoelectric Point: 7.6418
>NTDB_id=895588 R4702_RS07925 WP_000565017.1 1527906..1528565(-) (cclA/cilC) [Streptococcus pneumoniae strain 16P4028]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV
Nucleotide
Download Length: 660 bp
>NTDB_id=895588 R4702_RS07925 WP_000565017.1 1527906..1528565(-) (cclA/cilC) [Streptococcus pneumoniae strain 16P4028]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| cclA/cilC | Streptococcus pneumoniae TIGR4 |
96.804 |
100 |
0.968 |
| cclA/cilC | Streptococcus pneumoniae Rx1 |
95.89 |
100 |
0.959 |
| cclA/cilC | Streptococcus pneumoniae D39 |
95.89 |
100 |
0.959 |
| cclA/cilC | Streptococcus pneumoniae R6 |
95.89 |
100 |
0.959 |
| cclA/cilC | Streptococcus mitis SK321 |
92.237 |
100 |
0.922 |
| cclA/cilC | Streptococcus mitis NCTC 12261 |
85.845 |
100 |
0.858 |