Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4699_RS06880 Genome accession   NZ_CP137105
Coordinates   1364813..1365550 (-) Length   245 a.a.
NCBI ID   WP_001219124.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 16H2092     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1359813..1370550
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4699_RS06860 - 1360189..1361832 (+) 1644 Protein_1341 peptide cleavage/export ABC transporter -
  R4699_RS06865 - 1361843..1363204 (+) 1362 WP_050104729.1 bacteriocin secretion accessory protein -
  R4699_RS06870 blpC 1363261..1363416 (+) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  R4699_RS06875 - 1363459..1364799 (-) 1341 WP_050104728.1 sensor histidine kinase -
  R4699_RS06880 comE/blpR 1364813..1365550 (-) 738 WP_001219124.1 response regulator transcription factor Regulator
  R4699_RS06885 - 1365555..1365893 (-) 339 WP_000682123.1 LytTR family DNA-binding domain-containing protein -
  R4699_RS06890 - 1366170..1366499 (+) 330 WP_000132572.1 hypothetical protein -
  R4699_RS06895 - 1366667..1367716 (-) 1050 WP_000653751.1 ABC transporter permease -
  R4699_RS06900 pptA 1367713..1368444 (-) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  R4699_RS06905 - 1368512..1368922 (+) 411 WP_001278304.1 HIT family protein -
  R4699_RS06910 - 1368932..1369219 (+) 288 WP_050104727.1 hypothetical protein -
  R4699_RS06915 - 1369381..1369620 (+) 240 WP_001813906.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28692.86 Da        Isoelectric Point: 6.2357

>NTDB_id=895488 R4699_RS06880 WP_001219124.1 1364813..1365550(-) (comE/blpR) [Streptococcus pneumoniae strain 16H2092]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895488 R4699_RS06880 WP_001219124.1 1364813..1365550(-) (comE/blpR) [Streptococcus pneumoniae strain 16H2092]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.036

100

0.535
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384