Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   R4709_RS05465 Genome accession   NZ_CP137102
Coordinates   1057567..1058892 (+) Length   441 a.a.
NCBI ID   WP_317802303.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 16H3071-2     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1052567..1063892
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4709_RS05435 dnaA 1052906..1054267 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  R4709_RS05440 spo0J 1054480..1055238 (-) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  R4709_RS05445 htrA 1055296..1056477 (-) 1182 WP_000681601.1 S1C family serine protease Regulator
  R4709_RS05450 rlmH 1056660..1057139 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4709_RS05460 comC/comC1 1057421..1057546 (+) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  R4709_RS05465 comD/comD1 1057567..1058892 (+) 1326 WP_317802303.1 competence system sensor histidine kinase ComD Regulator
  R4709_RS05470 comE 1058889..1059641 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4709_RS05485 - 1059884..1060426 (-) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  R4709_RS05490 - 1060554..1062207 (+) 1654 Protein_1083 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51300.73 Da        Isoelectric Point: 6.5045

>NTDB_id=895249 R4709_RS05465 WP_317802303.1 1057567..1058892(+) (comD/comD1) [Streptococcus pneumoniae strain 16H3071-2]
MDLFGFGTVIVHFLIISHSYHFICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NCGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=895249 R4709_RS05465 WP_317802303.1 1057567..1058892(+) (comD/comD1) [Streptococcus pneumoniae strain 16H3071-2]
ATGGATTTATTTGGATTTGGGACGGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCATTTTATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGAAAGATTTTTATTTCCTTTGGGATTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACGAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATTGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

99.773

100

0.998
  comD/comD1 Streptococcus pneumoniae D39

99.773

100

0.998
  comD/comD1 Streptococcus pneumoniae R6

99.773

100

0.998
  comD/comD2 Streptococcus pneumoniae TIGR4

96.599

100

0.966
  comD Streptococcus mitis SK321

91.837

100

0.918
  comD Streptococcus mitis NCTC 12261

85.941

100

0.859
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419