Detailed information NTG0893250

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: R1Y14_RS06135
• Genome accession: NZ_CP136899
• Coordinates: 1186661..1188901 (+)
• Length: 746 a.a.
• NCBI ID: WP_000942428.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain ST62
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1181661..1193901

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R1Y14_RS06105 (R1Y14_06105)	-	1181811..1182779 (+)	969	WP_000658179.1	PhoH family protein	-
R1Y14_RS06110 (R1Y14_06110)	-	1182972..1183472 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
R1Y14_RS06115 (R1Y14_06115)	-	1183475..1183801 (+)	327	Protein_1169	TfoX/Sxy family protein	-
R1Y14_RS06120 (R1Y14_06120)	ald	1184102..1185213 (-)	1112	Protein_1170	alanine dehydrogenase	-
R1Y14_RS06125 (R1Y14_06125)	-	1185390..1185959 (+)	570	WP_000443775.1	GNAT family N-acetyltransferase	-
R1Y14_RS06130 (R1Y14_06130)	comEA/celA/cilE	1186027..1186677 (+)	651	WP_000387332.1	helix-hairpin-helix domain-containing protein	Machinery gene
R1Y14_RS06135 (R1Y14_06135)	comEC/celB	1186661..1188901 (+)	2241	WP_000942428.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
R1Y14_RS06140 (R1Y14_06140)	-	1189050..1189267 (+)	218	Protein_1174	hypothetical protein	-
R1Y14_RS06145 (R1Y14_06145)	-	1189300..1189887 (+)	588	WP_000939880.1	ATP-binding cassette domain-containing protein	-
R1Y14_RS06150 (R1Y14_06150)	-	1189891..1191072 (+)	1182	WP_000655935.1	membrane protein	-
R1Y14_RS06155 (R1Y14_06155)	infC	1191379..1191909 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
R1Y14_RS06160 (R1Y14_06160)	rpmI	1191942..1192142 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
R1Y14_RS06165 (R1Y14_06165)	rplT	1192194..1192553 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
R1Y14_RS06170 (R1Y14_06170)	-	1192611..1192991 (+)	381	WP_000157154.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84490.01 Da
• Isoelectric Point: 9.6237

>NTDB_id=893250 R1Y14_RS06135 WP_000942428.1 1186661..1188901(+) (comEC/celB) [Streptococcus pneumoniae strain ST62]
MLQWIKNIPIPLIYLSFLLLWFYYAIFSASYLALLGFVFLLVCLFFQFPWKSASKVLVICGIFGFWFVFQNWQQSQASQN
LADSVEGVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSLRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPTFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=893250 R1Y14_RS06135 WP_000942428.1 1186661..1188901(+) (comEC/celB) [Streptococcus pneumoniae strain ST62]
ATGTTACAGTGGATTAAGAACATCCCCATTCCCCTAATTTACCTGAGTTTTTTGTTACTTTGGTTTTATTACGCTATTTT
CTCAGCATCCTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCTA
GCAAAGTTCTAGTGATTTGTGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAGGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCTAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAACCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (30-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

• Competence protein (Competence) (216-458)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	97.453	100	0.975
comEC/celB	Streptococcus pneumoniae Rx1	95.845	100	0.958
comEC/celB	Streptococcus pneumoniae D39	95.845	100	0.958
comEC/celB	Streptococcus pneumoniae R6	95.845	100	0.958
comEC/celB	Streptococcus mitis SK321	91.823	100	0.918
comEC/celB	Streptococcus mitis NCTC 12261	91.275	99.866	0.912
comEC	Lactococcus lactis subsp. cremoris KW2	44.355	99.732	0.442