Detailed information NTG0864487

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: Q7618_RS02565
• Genome accession: NZ_CP131715
• Coordinates: 500374..501111 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 2006C08-243
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 495374..506111

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7618_RS02530 (Q7618_02525)	-	496304..496543 (-)	240	WP_001810235.1	hypothetical protein	-
Q7618_RS02535 (Q7618_02530)	-	496705..496992 (-)	288	WP_000777760.1	hypothetical protein	-
Q7618_RS02540 (Q7618_02535)	-	497002..497412 (-)	411	WP_001278300.1	HIT family protein	-
Q7618_RS02545 (Q7618_02540)	pptA	497480..498211 (+)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
Q7618_RS02550 (Q7618_02545)	-	498208..499257 (+)	1050	WP_000653767.1	ABC transporter permease	-
Q7618_RS02555 (Q7618_02550)	-	499425..499754 (-)	330	WP_000132572.1	hypothetical protein	-
Q7618_RS02560 (Q7618_02555)	-	500031..500369 (+)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
Q7618_RS02565 (Q7618_02560)	comE/blpR	500374..501111 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
Q7618_RS02570 (Q7618_02565)	-	501125..502465 (+)	1341	WP_001017638.1	sensor histidine kinase	-
Q7618_RS02575 (Q7618_02570)	blpC	502507..502662 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
Q7618_RS02580 (Q7618_02575)	-	502719..504080 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
Q7618_RS02585 (Q7618_02580)	comA/nlmT	504091..505767 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=864487 Q7618_RS02565 WP_001219120.1 500374..501111(+) (comE/blpR) [Streptococcus pneumoniae strain 2006C08-243]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=864487 Q7618_RS02565 WP_001219120.1 500374..501111(+) (comE/blpR) [Streptococcus pneumoniae strain 2006C08-243]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363