Detailed information NTG0864408

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: Q7619_RS02565
• Genome accession: NZ_CP131714
• Coordinates: 500759..501496 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 2008C04-309
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 495759..506496

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7619_RS02530 (Q7619_02525)	-	496689..496928 (-)	240	WP_001810235.1	hypothetical protein	-
Q7619_RS02535 (Q7619_02530)	-	497090..497377 (-)	288	WP_000777760.1	hypothetical protein	-
Q7619_RS02540 (Q7619_02535)	-	497387..497797 (-)	411	WP_001278300.1	HIT family protein	-
Q7619_RS02545 (Q7619_02540)	pptA	497865..498596 (+)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
Q7619_RS02550 (Q7619_02545)	-	498593..499642 (+)	1050	WP_000653767.1	ABC transporter permease	-
Q7619_RS02555 (Q7619_02550)	-	499810..500139 (-)	330	WP_000132572.1	hypothetical protein	-
Q7619_RS02560 (Q7619_02555)	-	500416..500754 (+)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
Q7619_RS02565 (Q7619_02560)	comE/blpR	500759..501496 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
Q7619_RS02570 (Q7619_02565)	-	501510..502850 (+)	1341	WP_001017638.1	sensor histidine kinase	-
Q7619_RS02575 (Q7619_02570)	blpC	502892..503047 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
Q7619_RS02580 (Q7619_02575)	-	503104..504465 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
Q7619_RS02585 (Q7619_02580)	comA/nlmT	504476..506152 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=864408 Q7619_RS02565 WP_001219120.1 500759..501496(+) (comE/blpR) [Streptococcus pneumoniae strain 2008C04-309]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=864408 Q7619_RS02565 WP_001219120.1 500759..501496(+) (comE/blpR) [Streptococcus pneumoniae strain 2008C04-309]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363