Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   Q7621_RS11005 Genome accession   NZ_CP131712
Coordinates   2202791..2204116 (-) Length   441 a.a.
NCBI ID   WP_341966604.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 2008C09-280     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2197791..2209116
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7621_RS10980 (Q7621_10965) - 2199476..2201078 (-) 1603 Protein_2125 YhgE/Pip domain-containing protein -
  Q7621_RS10985 (Q7621_10970) - 2201257..2201799 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  Q7621_RS11000 (Q7621_10985) comE 2202042..2202794 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  Q7621_RS11005 (Q7621_10990) comD/comD2 2202791..2204116 (-) 1326 WP_341966604.1 competence system sensor histidine kinase ComD Regulator
  Q7621_RS11010 (Q7621_10995) comC/comC2 2204137..2204262 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  Q7621_RS11020 (Q7621_11005) rlmH 2204544..2205023 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  Q7621_RS11025 (Q7621_11010) htrA 2205206..2206387 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  Q7621_RS11030 (Q7621_11015) spo0J 2206445..2207203 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51497.15 Da        Isoelectric Point: 7.5816

>NTDB_id=864314 Q7621_RS11005 WP_341966604.1 2202791..2204116(-) (comD/comD2) [Streptococcus pneumoniae strain 2008C09-280]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYIFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRVVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=864314 Q7621_RS11005 WP_341966604.1 2202791..2204116(-) (comD/comD2) [Streptococcus pneumoniae strain 2008C09-280]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACATTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGTAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.093

100

0.991
  comD/comD1 Streptococcus pneumoniae Rx1

96.372

100

0.964
  comD/comD1 Streptococcus pneumoniae D39

96.372

100

0.964
  comD/comD1 Streptococcus pneumoniae R6

96.372

100

0.964
  comD Streptococcus mitis SK321

91.61

100

0.916
  comD Streptococcus mitis NCTC 12261

86.395

100

0.864
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.198

84.807

0.417
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.936

85.261

0.417