Detailed information NTG0864313

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: Q7621_RS11000
• Genome accession: NZ_CP131712
• Coordinates: 2202042..2202794 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 2008C09-280
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2197042..2207794

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7621_RS10980 (Q7621_10965)	-	2199476..2201078 (-)	1603	Protein_2125	YhgE/Pip domain-containing protein	-
Q7621_RS10985 (Q7621_10970)	-	2201257..2201799 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
Q7621_RS11000 (Q7621_10985)	comE	2202042..2202794 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
Q7621_RS11005 (Q7621_10990)	comD/comD2	2202791..2204116 (-)	1326	WP_341966604.1	competence system sensor histidine kinase ComD	Regulator
Q7621_RS11010 (Q7621_10995)	comC/comC2	2204137..2204262 (-)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator
Q7621_RS11020 (Q7621_11005)	rlmH	2204544..2205023 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
Q7621_RS11025 (Q7621_11010)	htrA	2205206..2206387 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
Q7621_RS11030 (Q7621_11015)	spo0J	2206445..2207203 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=864313 Q7621_RS11000 WP_000866065.1 2202042..2202794(-) (comE) [Streptococcus pneumoniae strain 2008C09-280]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=864313 Q7621_RS11000 WP_000866065.1 2202042..2202794(-) (comE) [Streptococcus pneumoniae strain 2008C09-280]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATTGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408