NTDB

Overview

Name	cclA/cilC	Type	Machinery gene
Locus tag	Q7621_RS08635	Genome accession	NZ_CP131712
Coordinates	1760222..1760881 (+)	Length	219 a.a.
NCBI ID	WP_000565017.1	Uniprot ID	A0A0E8GKN8
Organism	Streptococcus pneumoniae strain 2008C09-280
Function	processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1755222..1765881

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7621_RS08610 (Q7621_08605)	-	1755527..1755844 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
Q7621_RS08615 (Q7621_08610)	-	1755859..1756755 (-)	897	WP_000825668.1	PEP phosphonomutase	-
Q7621_RS08620 (Q7621_08615)	-	1756758..1758020 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
Q7621_RS08625 (Q7621_08620)	-	1758300..1759478 (+)	1179	WP_000175872.1	ROK family transcriptional regulator	-
Q7621_RS08630 (Q7621_08625)	-	1759706..1760152 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
Q7621_RS08635 (Q7621_08630)	cclA/cilC	1760222..1760881 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
Q7621_RS08640 (Q7621_08635)	-	1760933..1762084 (-)	1152	WP_000481749.1	XRE family transcriptional regulator	-
Q7621_RS08645 (Q7621_08640)	-	1762099..1762830 (-)	732	WP_000934017.1	hypothetical protein	-
Q7621_RS08650 (Q7621_08645)	-	1763059..1763160 (+)	102	Protein_1712	prepilin peptidase	-
Q7621_RS08655 (Q7621_08650)	trpA	1763132..1763908 (-)	777	WP_001126993.1	tryptophan synthase subunit alpha	-
Q7621_RS08660 (Q7621_08655)	trpB	1763901..1765124 (-)	1224	WP_000331298.1	tryptophan synthase subunit beta	-
Q7621_RS08665 (Q7621_08660)	-	1765102..1765701 (-)	600	WP_000169888.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

Download Length: 219 a.a. Molecular weight: 24879.99 Da Isoelectric Point: 7.6418

                                >NTDB_id=864279 Q7621_RS08635 WP_000565017.1 1760222..1760881(+) (cclA/cilC) [Streptococcus pneumoniae strain 2008C09-280]

MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG

LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL

FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

Download Length: 660 bp

                                >NTDB_id=864279 Q7621_RS08635 WP_000565017.1 1760222..1760881(+) (cclA/cilC) [Streptococcus pneumoniae strain 2008C09-280]

ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA

ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC

AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA

CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT

CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA

ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC

TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT

GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG

GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0E8GKN8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858

Detailed information NTG0864279