Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   Q7622_RS04050 Genome accession   NZ_CP131711
Coordinates   796115..796774 (-) Length   219 a.a.
NCBI ID   WP_000565017.1    Uniprot ID   A0A0E8GKN8
Organism   Streptococcus pneumoniae strain 2014C08-275     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 775309..796063 796115..796774 flank 52


Gene organization within MGE regions


Location: 775309..796774
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7622_RS03940 (Q7622_03940) - 775309..776055 (+) 747 WP_000239016.1 protein phosphatase 2C domain-containing protein -
  Q7622_RS03945 (Q7622_03945) - 776113..776754 (+) 642 WP_000945331.1 phosphate uptake regulator PhoU -
  Q7622_RS03950 (Q7622_03950) galT 776767..778242 (+) 1476 WP_000848804.1 UDP-glucose--hexose-1-phosphate uridylyltransferase -
  Q7622_RS03955 (Q7622_03955) galE 778255..779265 (+) 1011 WP_000996571.1 UDP-glucose 4-epimerase GalE -
  Q7622_RS03960 (Q7622_03960) - 779432..780091 (+) 660 WP_000793811.1 DUF1868 domain-containing protein -
  Q7622_RS03965 (Q7622_03965) - 780116..781183 (+) 1068 WP_000738378.1 extracellular solute-binding protein -
  Q7622_RS03970 (Q7622_03970) - 781286..782296 (+) 1011 WP_000589139.1 ABC transporter ATP-binding protein -
  Q7622_RS03975 (Q7622_03975) - 782308..783999 (+) 1692 WP_001216176.1 iron ABC transporter permease -
  Q7622_RS03980 (Q7622_03980) - 784002..784712 (+) 711 WP_000127552.1 MgtC/SapB family protein -
  Q7622_RS03985 (Q7622_03985) - 784808..785175 (+) 368 Protein_788 hypothetical protein -
  Q7622_RS03990 (Q7622_03990) - 785283..786284 (+) 1002 WP_000789949.1 LacI family DNA-binding transcriptional regulator -
  Q7622_RS03995 (Q7622_03995) - 786892..787233 (+) 342 WP_000693162.1 hypothetical protein -
  Q7622_RS04000 (Q7622_04000) trpE 787605..788966 (+) 1362 WP_000439604.1 anthranilate synthase component I -
  Q7622_RS04005 (Q7622_04005) - 788963..789529 (+) 567 WP_000601920.1 aminodeoxychorismate/anthranilate synthase component II -
  Q7622_RS04010 (Q7622_04010) trpD 789540..790544 (+) 1005 WP_000658682.1 anthranilate phosphoribosyltransferase -
  Q7622_RS04015 (Q7622_04015) trpC 790541..791308 (+) 768 WP_000076535.1 indole-3-glycerol phosphate synthase TrpC -
  Q7622_RS04020 (Q7622_04020) - 791295..791894 (+) 600 WP_000169887.1 phosphoribosylanthranilate isomerase -
  Q7622_RS04025 (Q7622_04025) trpB 791872..793095 (+) 1224 WP_000331287.1 tryptophan synthase subunit beta -
  Q7622_RS04030 (Q7622_04030) trpA 793088..793864 (+) 777 WP_001127048.1 tryptophan synthase subunit alpha -
  Q7622_RS04035 (Q7622_04035) - 793836..793937 (-) 102 Protein_798 prepilin peptidase -
  Q7622_RS04040 (Q7622_04040) - 794166..794897 (+) 732 WP_000934017.1 hypothetical protein -
  Q7622_RS04045 (Q7622_04045) - 794912..796063 (+) 1152 WP_000481747.1 XRE family transcriptional regulator -
  Q7622_RS04050 (Q7622_04050) cclA/cilC 796115..796774 (-) 660 WP_000565017.1 A24 family peptidase Machinery gene

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24879.99 Da        Isoelectric Point: 7.6418

>NTDB_id=864180 Q7622_RS04050 WP_000565017.1 796115..796774(-) (cclA/cilC) [Streptococcus pneumoniae strain 2014C08-275]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=864180 Q7622_RS04050 WP_000565017.1 796115..796774(-) (cclA/cilC) [Streptococcus pneumoniae strain 2014C08-275]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E8GKN8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae Rx1

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae D39

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae R6

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

92.237

100

0.922
  cclA/cilC Streptococcus mitis NCTC 12261

85.845

100

0.858