Detailed information
Bioinformatically predicted
Overview
| Name | cclA/cilC | Type | Machinery gene |
| Locus tag | STYK_RS02570 | Genome accession | NZ_AP024523 |
| Coordinates | 477139..477798 (-) | Length | 219 a.a. |
| NCBI ID | WP_261805168.1 | Uniprot ID | - |
| Organism | Streptococcus toyakuensis strain TP1632 | ||
| Function | processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 455557..496547 | 477139..477798 | within | 0 |
Gene organization within MGE regions
Location: 455557..496547
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| STYK_RS02465 (STYK_04280) | - | 455557..456303 (+) | 747 | WP_023935650.1 | protein phosphatase 2C domain-containing protein | - |
| STYK_RS02470 (STYK_04290) | - | 456361..457002 (+) | 642 | WP_261805161.1 | phosphate signaling complex PhoU family protein | - |
| STYK_RS02475 (STYK_04300) | galT | 457015..458490 (+) | 1476 | WP_261023639.1 | UDP-glucose--hexose-1-phosphate uridylyltransferase | - |
| STYK_RS02480 (STYK_04310) | galE | 458503..459513 (+) | 1011 | WP_261805162.1 | UDP-glucose 4-epimerase GalE | - |
| STYK_RS02485 (STYK_04320) | - | 459697..460356 (+) | 660 | WP_000793811.1 | DUF1868 domain-containing protein | - |
| STYK_RS02490 (STYK_04330) | - | 460381..461448 (+) | 1068 | WP_000738380.1 | extracellular solute-binding protein | - |
| STYK_RS02495 (STYK_04340) | - | 461551..462561 (+) | 1011 | WP_000589137.1 | ABC transporter ATP-binding protein | - |
| STYK_RS02500 (STYK_04350) | - | 462573..464264 (+) | 1692 | WP_166732130.1 | ABC transporter permease | - |
| STYK_RS02505 (STYK_04360) | - | 464267..464977 (+) | 711 | WP_001149044.1 | MgtC/SapB family protein | - |
| STYK_RS02510 (STYK_04380) | - | 465664..466659 (+) | 996 | WP_000410752.1 | LacI family DNA-binding transcriptional regulator | - |
| STYK_RS02515 (STYK_04390) | trpB | 467266..468444 (+) | 1179 | WP_000208440.1 | tryptophan synthase subunit beta | - |
| STYK_RS02520 (STYK_04400) | trpE | 468738..470099 (+) | 1362 | WP_261805163.1 | anthranilate synthase component I | - |
| STYK_RS02525 (STYK_04410) | - | 470096..470662 (+) | 567 | WP_223336281.1 | aminodeoxychorismate/anthranilate synthase component II | - |
| STYK_RS02530 (STYK_04420) | trpD | 470673..471677 (+) | 1005 | WP_261805164.1 | anthranilate phosphoribosyltransferase | - |
| STYK_RS02535 (STYK_04430) | trpC | 471674..472441 (+) | 768 | WP_261805165.1 | indole-3-glycerol phosphate synthase TrpC | - |
| STYK_RS02540 (STYK_04440) | - | 472428..473027 (+) | 600 | WP_042768741.1 | phosphoribosylanthranilate isomerase | - |
| STYK_RS02545 (STYK_04450) | trpB | 473005..474228 (+) | 1224 | WP_261805166.1 | tryptophan synthase subunit beta | - |
| STYK_RS02550 (STYK_04460) | trpA | 474221..474997 (+) | 777 | WP_261805167.1 | tryptophan synthase subunit alpha | - |
| STYK_RS02555 | - | 474969..475070 (-) | 102 | Protein_450 | prepilin peptidase | - |
| STYK_RS02560 (STYK_04470) | - | 475191..475921 (+) | 731 | Protein_451 | hypothetical protein | - |
| STYK_RS02565 (STYK_04480) | - | 475936..477087 (+) | 1152 | WP_000481755.1 | XRE family transcriptional regulator | - |
| STYK_RS02570 (STYK_04490) | cclA/cilC | 477139..477798 (-) | 660 | WP_261805168.1 | prepilin peptidase | Machinery gene |
| STYK_RS02575 (STYK_04500) | - | 477868..478323 (+) | 456 | WP_261805169.1 | GNAT family N-acetyltransferase | - |
| STYK_RS02580 (STYK_04510) | - | 478476..478679 (-) | 204 | WP_049497560.1 | CsbD family protein | - |
| STYK_RS02585 (STYK_04520) | - | 478703..479311 (-) | 609 | WP_049497563.1 | Asp23/Gls24 family envelope stress response protein | - |
| STYK_RS02590 | - | 479377..479538 (-) | 162 | WP_000455067.1 | DUF2273 domain-containing protein | - |
| STYK_RS02595 (STYK_04530) | amaP | 479550..480122 (-) | 573 | WP_261805170.1 | alkaline shock response membrane anchor protein AmaP | - |
| STYK_RS02600 (STYK_04540) | - | 480199..480435 (-) | 237 | WP_049522036.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
| STYK_RS02605 (STYK_04550) | mgaSpn | 480721..481214 (+) | 494 | Protein_460 | virulence factor transcriptional regulator MgaSpn | - |
| STYK_RS02610 (STYK_04560) | - | 481270..481950 (-) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| STYK_RS02615 (STYK_04570) | - | 482012..482188 (+) | 177 | WP_261805171.1 | hypothetical protein | - |
| STYK_RS02620 (STYK_04580) | - | 482230..482901 (+) | 672 | WP_261805172.1 | hypothetical protein | - |
| STYK_RS02625 (STYK_04590) | - | 482891..483310 (+) | 420 | WP_261805173.1 | hypothetical protein | - |
| STYK_RS02630 | mobP2 | 483359..485727 (-) | 2369 | Protein_465 | MobP2 family relaxase | - |
| STYK_RS02635 | - | 485746..486306 (-) | 561 | Protein_466 | hypothetical protein | - |
| STYK_RS02640 (STYK_04640) | - | 486317..486766 (-) | 450 | WP_261805174.1 | hypothetical protein | - |
| STYK_RS02645 (STYK_04650) | - | 486777..487565 (-) | 789 | WP_261805175.1 | DNA/RNA non-specific endonuclease | - |
| STYK_RS02650 (STYK_04660) | - | 487568..487915 (-) | 348 | WP_049510603.1 | hypothetical protein | - |
| STYK_RS02655 (STYK_04670) | - | 487908..488241 (-) | 334 | Protein_470 | hypothetical protein | - |
| STYK_RS02660 (STYK_04680) | - | 488644..488931 (-) | 288 | WP_084939918.1 | hypothetical protein | - |
| STYK_RS02665 (STYK_04690) | - | 488965..489321 (-) | 357 | WP_261805176.1 | hypothetical protein | - |
| STYK_RS02670 (STYK_04700) | - | 489739..490740 (-) | 1002 | WP_261805177.1 | hypothetical protein | - |
| STYK_RS02675 (STYK_04710) | - | 490793..491017 (-) | 225 | WP_261805178.1 | multidrug transporter MATE | - |
| STYK_RS02680 (STYK_04720) | - | 491027..491257 (-) | 231 | WP_009730751.1 | hypothetical protein | - |
| STYK_RS02685 (STYK_04730) | - | 491250..491696 (-) | 447 | WP_261805179.1 | thioredoxin domain-containing protein | - |
| STYK_RS02690 (STYK_04740) | - | 491693..492115 (-) | 423 | WP_009730753.1 | hypothetical protein | - |
| STYK_RS02695 (STYK_04750) | - | 492131..492334 (-) | 204 | WP_261805180.1 | hypothetical protein | - |
| STYK_RS02700 (STYK_04760) | - | 492343..492504 (-) | 162 | WP_261805181.1 | hypothetical protein | - |
| STYK_RS02705 (STYK_04770) | - | 492593..494095 (-) | 1503 | WP_261805182.1 | primase C-terminal domain-containing protein | - |
| STYK_RS02710 (STYK_04780) | - | 494127..494372 (-) | 246 | WP_261805183.1 | synthase | - |
| STYK_RS02715 (STYK_04790) | - | 494416..494727 (-) | 312 | WP_261805184.1 | hypothetical protein | - |
| STYK_RS02720 | - | 494752..495423 (-) | 672 | Protein_483 | DUF2786 domain-containing protein | - |
| STYK_RS02725 (STYK_04820) | - | 495425..495886 (-) | 462 | WP_009730759.1 | hypothetical protein | - |
| STYK_RS02730 (STYK_04830) | - | 495890..496390 (-) | 501 | WP_261805185.1 | modification methylase Sau96I | - |
Sequence
Protein
Download Length: 219 a.a. Molecular weight: 24935.10 Da Isoelectric Point: 7.1427
>NTDB_id=85733 STYK_RS02570 WP_261805168.1 477139..477798(-) (cclA/cilC) [Streptococcus toyakuensis strain TP1632]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISPASHCDSCQTRLRPLDLIPILSQVLNRFRCRYCKDPYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFQLILMASSGWNLVMIFFLVLGMLAHFIDIRMGAGDFL
FLASCSLVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV
MIDFYFFLVGSILASFLGLVIDRFPEQSIISPASHCDSCQTRLRPLDLIPILSQVLNRFRCRYCKDPYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFQLILMASSGWNLVMIFFLVLGMLAHFIDIRMGAGDFL
FLASCSLVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV
Nucleotide
Download Length: 660 bp
>NTDB_id=85733 STYK_RS02570 WP_261805168.1 477139..477798(-) (cclA/cilC) [Streptococcus toyakuensis strain TP1632]
ATGATTGATTTTTATTTTTTTCTTGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTCCAGCTAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCTC
AGGTACTCAATCGCTTTCGCTGTCGCTACTGCAAGGATCCTTATCCAGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGG
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACCGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGTCATCAGGAATACCCCTTACTGGTCTGGATGACTTTCCAACTAATCCTCATGGCTTCCTCTGGCTGGA
ATCTGGTCATGATCTTCTTCCTTGTCCTTGGAATGTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTTCTC
TTTTTAGCTTCCTGCTCTCTCGTCTTTAGCGTAACGGAGTTGCTCATCTTGATTCAGTTTGCTTCTGCAACTGGCATCCT
AGCTTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTTGTGCCTTTCCTCTTACTCGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA
ATGATTGATTTTTATTTTTTTCTTGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTCCAGCTAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCTC
AGGTACTCAATCGCTTTCGCTGTCGCTACTGCAAGGATCCTTATCCAGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGG
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACCGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGTCATCAGGAATACCCCTTACTGGTCTGGATGACTTTCCAACTAATCCTCATGGCTTCCTCTGGCTGGA
ATCTGGTCATGATCTTCTTCCTTGTCCTTGGAATGTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTTCTC
TTTTTAGCTTCCTGCTCTCTCGTCTTTAGCGTAACGGAGTTGCTCATCTTGATTCAGTTTGCTTCTGCAACTGGCATCCT
AGCTTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTTGTGCCTTTCCTCTTACTCGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| cclA/cilC | Streptococcus pneumoniae Rx1 |
94.521 |
100 |
0.945 |
| cclA/cilC | Streptococcus pneumoniae D39 |
94.521 |
100 |
0.945 |
| cclA/cilC | Streptococcus pneumoniae R6 |
94.521 |
100 |
0.945 |
| cclA/cilC | Streptococcus mitis SK321 |
92.694 |
100 |
0.927 |
| cclA/cilC | Streptococcus pneumoniae TIGR4 |
91.324 |
100 |
0.913 |
| cclA/cilC | Streptococcus mitis NCTC 12261 |
88.128 |
100 |
0.881 |