Detailed information NTG0848215

Bioinformatically predicted

Overview

• Name: pilC
• Type: Machinery gene
• Locus tag: QTV68_RS04220
• Genome accession: NZ_CP128516
• Coordinates: 812451..813647 (+)
• Length: 398 a.a.
• NCBI ID: WP_006248403.1
• Uniprot ID: A0A249A0I8
• Organism: Mannheimia haemolytica strain 192916
• Function: type IV pilus biogenesis and function (predicted from homology) DNA binding and uptake

Genomic Context

Location: 807451..818647

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QTV68_RS04190	proB	807847..808931 (-)	1085	Protein_803	glutamate 5-kinase	-
QTV68_RS04195	folA	809043..809537 (+)	495	WP_006248397.1	type 3 dihydrofolate reductase	-
QTV68_RS04200	-	809657..809887 (+)	231	WP_006248398.1	YgjV family protein	-
QTV68_RS04205	radA	809942..811321 (-)	1380	WP_006248399.1	DNA repair protein RadA	-
QTV68_RS04210	pilA	811502..811981 (+)	480	WP_006248401.1	prepilin peptidase-dependent pilin	Machinery gene
QTV68_RS04215	-	812002..812445 (+)	444	Protein_808	pilus assembly protein PilB	-
QTV68_RS04220	pilC	812451..813647 (+)	1197	WP_006248403.1	type II secretion system F family protein	Machinery gene
QTV68_RS04225	-	813650..814306 (+)	657	WP_006248404.1	prepilin peptidase	-
QTV68_RS04230	coaE	814342..814977 (+)	636	WP_006248405.1	dephospho-CoA kinase	-
QTV68_RS04235	yacG	814959..815144 (+)	186	WP_006248406.1	DNA gyrase inhibitor YacG	-
QTV68_RS04240	holA	815145..816170 (-)	1026	WP_006253426.1	DNA polymerase III subunit delta	-
QTV68_RS04245	lptE	816213..816701 (-)	489	WP_006248408.1	LPS assembly lipoprotein LptE	-

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 45186.75 Da
• Isoelectric Point: 9.4698

>NTDB_id=848215 QTV68_RS04220 WP_006248403.1 812451..813647(+) (pilC) [Mannheimia haemolytica strain 192916]
MTKIYEFHWQAQSRFGQKQRGKRLATNRDMLENLLLAQGYQHIRISRNFVLSANPKKEEVNSLLSQLALLVNSAMPLKQA
LSMLLQNCRNIRLYLWLNELIQHIESGYAFSQSLEKLGEFVTNQEIQLIKMGEQSGKLGIMLTNLAESRAKLEKLAKKVK
KILFYPVIVLLISLALSIGLLVLIVPQFAQLYGSKDKTLPLITDILFTLSECLIEQGTVLLGTLLLAVIFYLFFAKKSRL
VAKWKMALWAKMPLFSRIIEQSRIIFFSQNIALMLNAHIPLDVALRSFLSEKNDDPILQQEIGTMLNLLQQGYKFSQGIN
PNVFGAEMAQMLEVGEKSGNVAKMCEHISEMYQQKLDYQIDILSQLLEPMLMLIMGVIVGTIIVGLYLPIFDMGALVE

Nucleotide

• Length: 1197 bp

>NTDB_id=848215 QTV68_RS04220 WP_006248403.1 812451..813647(+) (pilC) [Mannheimia haemolytica strain 192916]
ATGACGAAAATCTATGAATTTCATTGGCAAGCCCAGAGCCGATTTGGGCAAAAACAGCGGGGCAAGCGGTTGGCAACGAA
TCGAGACATGTTGGAAAACCTTTTGCTGGCACAAGGTTATCAGCATATTCGGATTAGCCGAAATTTTGTGCTTTCAGCAA
ACCCGAAAAAAGAAGAGGTGAATAGCTTGCTATCACAGCTTGCATTGTTGGTTAATTCTGCCATGCCGTTAAAACAGGCA
TTATCTATGTTGTTGCAAAACTGCCGAAATATCCGCCTTTATCTATGGCTTAATGAGCTGATTCAGCATATTGAAAGTGG
CTATGCTTTTTCACAATCGTTGGAGAAATTGGGTGAATTTGTGACCAATCAGGAAATTCAGCTAATCAAAATGGGCGAAC
AAAGCGGAAAACTGGGCATTATGCTGACTAATTTAGCTGAAAGCCGAGCGAAATTGGAAAAATTGGCGAAAAAAGTGAAG
AAAATCCTGTTTTACCCGGTGATTGTGTTGCTGATTTCGCTCGCTTTATCTATCGGGCTATTGGTTTTGATTGTACCGCA
GTTTGCCCAACTTTATGGCTCAAAAGACAAAACTTTACCCCTCATTACCGATATTTTATTTACCCTTTCCGAATGCTTGA
TTGAGCAAGGCACAGTATTACTTGGCACGTTACTACTAGCGGTCATTTTTTACCTGTTTTTTGCAAAAAAGAGCAGGTTA
GTCGCAAAGTGGAAAATGGCTCTATGGGCTAAAATGCCACTGTTTAGCCGAATTATTGAGCAATCTCGCATTATCTTTTT
CAGCCAAAATATTGCCTTAATGCTGAATGCTCATATTCCGCTTGATGTTGCCTTGAGGTCGTTTTTATCCGAGAAAAATG
ATGACCCGATTTTACAGCAAGAAATTGGCACTATGCTTAATTTGTTACAACAAGGCTACAAATTTTCACAAGGGATCAAC
CCGAATGTGTTTGGTGCTGAGATGGCACAAATGCTTGAGGTTGGGGAGAAAAGTGGCAATGTGGCGAAAATGTGTGAGCA
TATTAGTGAGATGTACCAACAAAAATTAGATTACCAAATTGATATTTTGTCTCAGCTATTAGAACCGATGCTAATGTTGA
TAATGGGCGTGATTGTCGGCACTATTATTGTTGGGCTGTATTTACCGATTTTTGATATGGGGGCTTTGGTGGAGTAG

Domains

Predicted by InterproScan.

• Type II secretion system (T2SS), protein F (T2SSF) (64-186)

• Type II secretion system (T2SS), protein F (T2SSF) (267-389)

3D structure

• AlphaFold DB: A0A249A0I8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilC	Glaesserella parasuis strain SC1401	54	100	0.543
pilC	Haemophilus influenzae Rd KW20	42.145	100	0.425
pilC	Haemophilus influenzae 86-028NP	41.147	100	0.415