Detailed information NTG0833163

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QM319_RS09355
• Genome accession: NZ_CP125863
• Coordinates: 1932634..1933677 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 19-00012
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1927634..1938677

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QM319_RS09325 (QM319_09315)	-	1928055..1929311 (-)	1257	WP_074347694.1	aminopeptidase	-
QM319_RS09330 (QM319_09320)	-	1929314..1929514 (-)	201	WP_000180460.1	DUF1128 family protein	-
QM319_RS09335 (QM319_09325)	-	1929661..1930125 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QM319_RS09340 (QM319_09330)	-	1930132..1930407 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
QM319_RS09345 (QM319_09335)	-	1930685..1931902 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
QM319_RS09350 (QM319_09340)	vraR	1932015..1932644 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QM319_RS09355 (QM319_09345)	vraS	1932634..1933677 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QM319_RS09360 (QM319_09350)	liaF	1933674..1934375 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QM319_RS09365 (QM319_09355)	-	1934390..1934776 (-)	387	WP_001110182.1	hypothetical protein	-
QM319_RS09370 (QM319_09360)	map	1934993..1935751 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
QM319_RS09375 (QM319_09365)	-	1936335..1937321 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
QM319_RS09380 (QM319_09370)	-	1937510..1937923 (-)	414	WP_025174370.1	hypothetical protein	-
QM319_RS09385 (QM319_09375)	-	1937952..1938062 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=833163 QM319_RS09355 WP_001017131.1 1932634..1933677(-) (vraS) [Staphylococcus aureus strain 19-00012]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=833163 QM319_RS09355 WP_001017131.1 1932634..1933677(-) (vraS) [Staphylococcus aureus strain 19-00012]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1