NTDB

Overview

Name	ciaH	Type	Regulator
Locus tag	QLH56_RS00615	Genome accession	NZ_CP125107
Coordinates	121601..122911 (-)	Length	436 a.a.
NCBI ID	WP_003099509.1	Uniprot ID	A0A3L8GJR1
Organism	Streptococcus iniae strain DFSM220524
Function	Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 116601..127911

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QLH56_RS00585 (QLH56_00585)	-	117033..117437 (-)	405	WP_230453495.1	cytidine deaminase	-
QLH56_RS00590 (QLH56_00590)	deoC	117409..118071 (-)	663	WP_003099517.1	deoxyribose-phosphate aldolase	-
QLH56_RS00595 (QLH56_00595)	-	118083..119360 (-)	1278	WP_003099515.1	pyrimidine-nucleoside phosphorylase	-
QLH56_RS00600 (QLH56_00600)	-	119347..119946 (-)	600	WP_003099513.1	class I SAM-dependent methyltransferase	-
QLH56_RS00605 (QLH56_00605)	coaA	120207..121127 (+)	921	WP_003099512.1	type I pantothenate kinase	-
QLH56_RS00610 (QLH56_00610)	rpsT	121187..121429 (+)	243	WP_080613191.1	30S ribosomal protein S20	-
QLH56_RS00615 (QLH56_00615)	ciaH	121601..122911 (-)	1311	WP_003099509.1	HAMP domain-containing sensor histidine kinase	Regulator
QLH56_RS00620 (QLH56_00620)	ciaR	122904..123578 (-)	675	WP_003099507.1	response regulator transcription factor	Regulator
QLH56_RS00625 (QLH56_00625)	-	123699..126236 (-)	2538	WP_003099506.1	M1 family metallopeptidase	-
QLH56_RS00630 (QLH56_00630)	phoU	126298..126951 (-)	654	WP_003099503.1	phosphate signaling complex protein PhoU	-
QLH56_RS00635 (QLH56_00635)	pstB	127006..127764 (-)	759	WP_003099501.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

Download Length: 436 a.a. Molecular weight: 49969.52 Da Isoelectric Point: 9.1099

                                >NTDB_id=829938 QLH56_RS00615 WP_003099509.1 121601..122911(-) (ciaH) [Streptococcus iniae strain DFSM220524]

MANLKRIYQSDNFGHFFHFFAVFTGIFVVMTMIIIQIMQYGVYSSVDSSLLAVSKNSSVYANLTMERMTSFYFDNQEDAF

KNGTEVFKAALVEQPVANTDIILFSSNGTVLNSFDALSGFQNFTLKTNELNAIRTRKLMNFYGHEEKYHTLTVKIHSNRY

PAVAYLMAVVNVEQLDRANERYERIIVLVMITFWFISVLASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR

LETLFRKPNETILENSEPIASSLEEVRNMKILTTNLLNLARRDDGINPELVDVDASFFDAMFENFNLVAEDYGKDFHFEN

QVKRTIKMDKSLLKQLITILFDNALKYTDSDGQISISVRTTDKNLMVRVLDDGPGIKDMDKKKVFDRFYRVDKARTRTKG

GFGLGLSLAKQIVASLNGTISVKDNKPKGTIFEVKL

Nucleotide

Download Length: 1311 bp

                                >NTDB_id=829938 QLH56_RS00615 WP_003099509.1 121601..122911(-) (ciaH) [Streptococcus iniae strain DFSM220524]

ATGGCTAATTTAAAACGTATTTACCAGTCAGATAATTTTGGGCATTTTTTCCATTTTTTTGCAGTCTTTACAGGAATATT

TGTTGTCATGACCATGATTATCATTCAAATCATGCAGTACGGTGTTTATTCTTCGGTAGATAGTAGTCTACTTGCTGTGT

CAAAAAATTCATCGGTTTATGCTAATTTAACCATGGAACGAATGACCTCATTTTACTTTGATAATCAAGAGGATGCTTTT

AAAAATGGAACTGAAGTCTTTAAAGCAGCCTTAGTTGAACAACCAGTTGCCAATACGGATATTATCCTCTTTAGTTCTAA

CGGAACGGTTTTAAATAGCTTTGATGCGCTATCGGGTTTTCAAAATTTTACCTTAAAAACAAATGAATTAAATGCCATTC

GAACACGGAAATTGATGAATTTTTACGGGCATGAAGAAAAATACCATACGCTGACAGTTAAGATTCATTCCAATAGGTAC

CCAGCGGTGGCTTACCTAATGGCAGTTGTCAATGTGGAACAATTGGACCGTGCCAATGAGCGCTATGAACGAATCATTGT

TCTTGTTATGATAACTTTCTGGTTTATTTCTGTTTTGGCCAGTATATACCTTGCAAAATGGAGTCGTAAACCAATTCTTG

AAAGTTATGAGAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGAACTCCCTTAGCAGTATTACAAAATCGC

TTAGAGACCCTGTTTAGAAAACCTAATGAAACAATTCTGGAAAACAGTGAACCAATTGCTTCGAGTTTAGAAGAAGTGCG

CAATATGAAGATCTTAACCACAAATTTATTGAATCTTGCCAGACGCGATGATGGGATTAATCCAGAACTCGTTGATGTGG

ATGCAAGCTTTTTTGACGCTATGTTTGAAAACTTCAACTTAGTAGCTGAAGATTATGGTAAAGACTTCCATTTTGAAAAT

CAGGTTAAGCGGACAATAAAAATGGATAAATCTTTATTAAAACAATTGATTACCATTTTATTTGATAATGCTTTGAAATA

CACGGACTCTGATGGGCAAATTTCAATTAGTGTTCGAACAACAGATAAAAATTTAATGGTCAGAGTGCTAGATGATGGTC

CTGGAATAAAAGACATGGATAAAAAGAAAGTTTTTGACCGCTTCTATCGTGTTGATAAGGCTAGAACACGTACTAAAGGT

GGATTTGGTTTGGGACTTTCTTTAGCAAAACAGATTGTTGCTTCCTTAAATGGAACAATATCAGTTAAAGACAATAAACC

AAAAGGGACAATATTTGAAGTTAAACTCTAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(220-285)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(329-436)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A3L8GJR1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaH	Streptococcus mutans UA159	57.275	99.312	0.569
ciaH	Streptococcus pneumoniae Rx1	51.835	100	0.518
ciaH	Streptococcus pneumoniae D39	51.835	100	0.518
ciaH	Streptococcus pneumoniae R6	51.835	100	0.518
ciaH	Streptococcus pneumoniae TIGR4	51.835	100	0.518

Detailed information NTG0829938