Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   H7677_RS00340 Genome accession   NZ_AP023391
Coordinates   57204..58103 (+) Length   299 a.a.
NCBI ID   WP_172060541.1    Uniprot ID   A0AAJ2PG12
Organism   Streptococcus suis strain DAT299     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 44574..56254 57204..58103 flank 950


Gene organization within MGE regions


Location: 44574..58103
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7677_RS00270 (DAT299_00340) purB 44574..45872 (+) 1299 WP_061767920.1 adenylosuccinate lyase -
  H7677_RS00275 (DAT299_00350) - 45878..46735 (+) 858 WP_044754794.1 hypothetical protein -
  H7677_RS00280 (DAT299_00360) - 46756..47274 (+) 519 Protein_37 lyase family protein -
  H7677_RS00285 (DAT299_00370) - 47679..48503 (+) 825 WP_024416929.1 ABC transporter ATP-binding protein -
  H7677_RS00290 (DAT299_00380) - 48496..49239 (+) 744 WP_044689728.1 ABC transporter permease -
  H7677_RS00295 (DAT299_00400) - 49565..50293 (+) 729 WP_184493683.1 amino acid transporter -
  H7677_RS00300 - 50303..50881 (+) 579 WP_184493685.1 CPBP family intramembrane glutamic endopeptidase -
  H7677_RS00305 (DAT299_00410) - 50896..51324 (+) 429 WP_184493687.1 Msa family membrane protein -
  H7677_RS00310 (DAT299_00420) - 51317..52189 (+) 873 WP_029184817.1 ABC transporter ATP-binding protein -
  H7677_RS00315 (DAT299_00430) - 52195..52965 (+) 771 WP_184493689.1 hypothetical protein -
  H7677_RS00320 (DAT299_00440) - 52968..54683 (+) 1716 WP_184493691.1 ABC transporter ATP-binding protein -
  H7677_RS00325 (DAT299_00450) - 54785..54958 (+) 174 WP_014637276.1 hypothetical protein -
  H7677_RS00330 (DAT299_00460) ruvB 55253..56254 (+) 1002 WP_024377694.1 Holliday junction branch migration DNA helicase RuvB -
  H7677_RS00335 (DAT299_00470) - 56322..56957 (+) 636 WP_172060542.1 HAD-IA family hydrolase -
  H7677_RS00340 (DAT299_00480) comR 57204..58103 (+) 900 WP_172060541.1 helix-turn-helix domain-containing protein Regulator

Sequence

Protein


Download         Length: 299 a.a.        Molecular weight: 35236.21 Da        Isoelectric Point: 4.6321

>NTDB_id=82868 H7677_RS00340 WP_172060541.1 57204..58103(+) (comR) [Streptococcus suis strain DAT299]
MNDKEFGQRVRQLRESASMTREQFCDDELELSVRQLTRIEAGTSKPTFSKIQYIATRLGMGLYELMPDYVSLPERYSKLK
FDVLRTPTYGNEELVEKRDAIMTEIYDDYYDDLPEEEKIAIDAIQSRIDTLESGTAGFGKEILEDYFEQIFRKQKYEVND
LLIIRLQLEYVRLSSNDSEIFRQFLKIIEALHGQIDIINSSDLFVLRDTLLSCVNILGSKKYYEPIPKIFDSVDKIIRLT
QDFQKKPIVSVLKWKYALFVNKDRGEAEKHYLDAILFAKLIENRELEQKIEEDWKVDNQ

Nucleotide


Download         Length: 900 bp        

>NTDB_id=82868 H7677_RS00340 WP_172060541.1 57204..58103(+) (comR) [Streptococcus suis strain DAT299]
ATGAACGATAAGGAATTTGGACAGCGTGTACGTCAATTACGAGAATCTGCTAGTATGACACGTGAACAGTTTTGTGACGA
TGAACTGGAACTCTCTGTGCGCCAATTAACTCGTATTGAAGCAGGTACTTCCAAGCCGACTTTTTCAAAGATTCAGTATA
TTGCAACTCGTTTAGGTATGGGACTTTACGAGCTTATGCCAGATTACGTATCCTTACCCGAAAGATATTCCAAGCTGAAA
TTTGATGTGCTTCGCACACCGACTTACGGAAACGAAGAGTTGGTTGAAAAACGAGATGCTATCATGACGGAAATCTACGA
TGACTATTATGATGACTTGCCTGAGGAGGAGAAAATAGCGATAGATGCGATTCAATCACGAATTGATACCTTAGAGTCAG
GGACAGCAGGCTTTGGAAAAGAGATACTGGAAGATTACTTTGAACAAATTTTTCGAAAACAAAAGTACGAAGTGAATGAT
TTACTGATTATTAGGCTCCAGCTCGAATATGTTAGGTTATCTAGTAATGATTCAGAAATATTTAGACAGTTTTTGAAAAT
TATAGAAGCCTTACATGGACAAATTGATATCATCAATTCAAGTGATTTATTTGTTTTACGAGATACATTGTTATCTTGTG
TAAATATTTTGGGAAGCAAAAAGTATTATGAACCAATACCAAAGATATTCGACAGTGTAGATAAAATTATTCGGTTGACA
CAAGATTTTCAGAAAAAGCCAATTGTCAGTGTATTGAAATGGAAATACGCACTTTTTGTAAATAAGGATAGAGGTGAGGC
TGAAAAGCATTATCTAGATGCGATTCTATTTGCAAAATTGATAGAAAATAGAGAGTTAGAACAGAAGATTGAAGAAGATT
GGAAAGTTGACAATCAATAA

Domains

Predicted by InterproScan.

Helix-turn-helix domain (HTH_31)

(5-60)

ComR tetratricopeptide (ComR_TPR)

(73-294)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus suis P1/7

93.311

100

0.933
  comR Streptococcus suis 05ZYH33

93.311

100

0.933
  comR Streptococcus suis D9

61.13

100

0.615
  comR Streptococcus mutans UA159

45.485

100

0.455
  comR Streptococcus pyogenes MGAS315

37.374

99.331

0.371

Multiple sequence alignment