Detailed information NTG0082815

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H7676_RS00330
• Genome accession: NZ_AP023390
• Coordinates: 52882..53793 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain KUN-0014944
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47882..58793

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7676_RS00310 (KUN4944_00270)	purE	48469..48960 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
H7676_RS00315 (KUN4944_00280)	purK	48947..50020 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
H7676_RS00320 (KUN4944_00290)	-	50022..51440 (+)	1419	WP_023612101.1	hypothetical protein	-
H7676_RS00325 (KUN4944_00300)	purB	51460..52752 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
H7676_RS00330 (KUN4944_00310)	comR	52882..53793 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
H7676_RS08680	comS	53877..53972 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
H7676_RS00335 (KUN4944_00320)	ruvB	54019..55017 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
H7676_RS00340 (KUN4944_00330)	-	55155..55592 (+)	438	WP_020904819.1	low molecular weight protein-tyrosine-phosphatase	-
H7676_RS00345 (KUN4944_00340)	-	55616..56017 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
H7676_RS00350 (KUN4944_00350)	-	56014..57789 (+)	1776	WP_014407199.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=82815 H7676_RS00330 WP_002986681.1 52882..53793(+) (comR) [Streptococcus pyogenes strain KUN-0014944]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=82815 H7676_RS00330 WP_002986681.1 52882..53793(+) (comR) [Streptococcus pyogenes strain KUN-0014944]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAGGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462