Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   H7674_RS07560 Genome accession   NZ_AP023388
Coordinates   1537720..1538406 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NIH35     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1532720..1543406
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7674_RS07540 (SPNIH35_14450) dnaI 1533441..1534343 (-) 903 WP_011284517.1 primosomal protein DnaI -
  H7674_RS07545 (SPNIH35_14460) - 1534344..1535519 (-) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  H7674_RS07550 (SPNIH35_14470) nrdR 1535503..1535997 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  H7674_RS07555 (SPNIH35_14480) covS 1536212..1537714 (-) 1503 WP_011284516.1 two-component system sensor histidine kinase CovS -
  H7674_RS07560 (SPNIH35_14490) covR 1537720..1538406 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  H7674_RS07565 (SPNIH35_14500) - 1538673..1539206 (-) 534 WP_011054200.1 YceD family protein -
  H7674_RS07570 (SPNIH35_14510) htpX 1539440..1540336 (-) 897 WP_011284515.1 zinc metalloprotease HtpX -
  H7674_RS07575 (SPNIH35_14520) - 1540383..1540940 (-) 558 WP_002985956.1 LemA family protein -
  H7674_RS07580 (SPNIH35_14530) rsmG 1541090..1541803 (+) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H7674_RS07585 (SPNIH35_14540) ktrB 1541888..1543264 (+) 1377 WP_032459750.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=82751 H7674_RS07560 WP_002991052.1 1537720..1538406(-) (covR) [Streptococcus pyogenes strain NIH35]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=82751 H7674_RS07560 WP_002991052.1 1537720..1538406(-) (covR) [Streptococcus pyogenes strain NIH35]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
CGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment