Detailed information NTG0082741

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: H7674_RS05685
• Genome accession: NZ_AP023388
• Coordinates: 1142031..1143260 (-)
• Length: 409 a.a.
• NCBI ID: WP_002984948.1
• Uniprot ID: A0A4U7GJW1
• Organism: Streptococcus pyogenes strain NIH35
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1137031..1148260

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7674_RS05665 (SPNIH35_10720)	rpiA	1137314..1137997 (-)	684	WP_011284704.1	ribose-5-phosphate isomerase RpiA	-
H7674_RS05670 (SPNIH35_10730)	-	1138375..1140474 (+)	2100	WP_011284703.1	AAA family ATPase	-
H7674_RS05675 (SPNIH35_10740)	-	1140532..1141274 (-)	743	Protein_1072	hypothetical protein	-
H7674_RS05680 (SPNIH35_10750)	yihA	1141422..1142021 (-)	600	WP_011284702.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
H7674_RS05685 (SPNIH35_10760)	clpX	1142031..1143260 (-)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
H7674_RS05690 (SPNIH35_10780)	-	1143580..1144077 (-)	498	WP_011284701.1	dihydrofolate reductase	-
H7674_RS05695 (SPNIH35_10790)	-	1144157..1144996 (-)	840	WP_011017679.1	thymidylate synthase	-
H7674_RS05700 (SPNIH35_10800)	-	1145205..1146380 (+)	1176	WP_021340971.1	hydroxymethylglutaryl-CoA synthase	-
H7674_RS05705 (SPNIH35_10810)	-	1146367..1147644 (+)	1278	WP_011284699.1	hydroxymethylglutaryl-CoA reductase, degradative	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 44991.44 Da
• Isoelectric Point: 4.5775

>NTDB_id=82741 H7674_RS05685 WP_002984948.1 1142031..1143260(-) (clpX) [Streptococcus pyogenes strain NIH35]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=82741 H7674_RS05685 WP_002984948.1 1142031..1143260(-) (clpX) [Streptococcus pyogenes strain NIH35]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCCCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAGCGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATTGAAGAAA
CGATGTTAGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

3D structure

• AlphaFold DB: A0A4U7GJW1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.603	98.044	0.575