Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   P8191_RS07230 Genome accession   NZ_CP121250
Coordinates   1381048..1381959 (-) Length   303 a.a.
NCBI ID   WP_029714263.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 1044     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1376048..1386959
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8191_RS07210 (P8191_07210) - 1377053..1378828 (-) 1776 WP_010921782.1 acyltransferase family protein -
  P8191_RS07215 (P8191_07215) - 1378825..1379226 (-) 402 WP_010921781.1 MORN repeat-containing protein -
  P8191_RS07220 (P8191_07220) - 1379249..1379686 (-) 438 WP_002994668.1 low molecular weight phosphotyrosine protein phosphatase -
  P8191_RS07225 (P8191_07225) ruvB 1379824..1380822 (-) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  P8191_RS07230 (P8191_07230) comR 1381048..1381959 (-) 912 WP_029714263.1 transcriptional regulator Rgg4/ComR Regulator
  P8191_RS07235 (P8191_07235) purB 1382091..1383383 (-) 1293 WP_010921780.1 adenylosuccinate lyase -
  P8191_RS07240 (P8191_07240) - 1383401..1385044 (-) 1644 WP_010921779.1 AIPR family protein -
  P8191_RS07245 (P8191_07245) purK 1385071..1386144 (-) 1074 WP_029714261.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  P8191_RS07250 (P8191_07250) purE 1386131..1386622 (-) 492 WP_002987716.1 5-(carboxyamino)imidazole ribonucleotide mutase -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35787.30 Da        Isoelectric Point: 4.4858

>NTDB_id=811352 P8191_RS07230 WP_029714263.1 1381048..1381959(-) (comR) [Streptococcus pyogenes strain 1044]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQTTLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=811352 P8191_RS07230 WP_029714263.1 1381048..1381959(-) (comR) [Streptococcus pyogenes strain 1044]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGACAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(73-296)

Helix-turn-helix (HTH_3)

(12-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.67

100

0.997
  comR Streptococcus pyogenes MGAS315

58.14

99.34

0.578
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462