Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   P8191_RS05995 Genome accession   NZ_CP121250
Coordinates   1142150..1142836 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 1044     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1137150..1147836
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8191_RS05975 (P8191_05975) dnaI 1137870..1138772 (-) 903 WP_002991016.1 primosomal protein DnaI -
  P8191_RS05980 (P8191_05980) - 1138773..1139948 (-) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  P8191_RS05985 (P8191_05985) nrdR 1139932..1140426 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  P8191_RS05990 (P8191_05990) covS 1140641..1142144 (-) 1504 Protein_1194 two-component system sensor histidine kinase CovS -
  P8191_RS05995 (P8191_05995) covR 1142150..1142836 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  P8191_RS06000 (P8191_06000) - 1143103..1143636 (-) 534 WP_011054200.1 DUF177 domain-containing protein -
  P8191_RS06005 (P8191_06005) htpX 1143870..1144766 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  P8191_RS06010 (P8191_06010) - 1144813..1145370 (-) 558 WP_002985956.1 LemA family protein -
  P8191_RS06015 (P8191_06015) rsmG 1145520..1146233 (+) 714 WP_010921904.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  P8191_RS06020 (P8191_06020) ktrB 1146318..1147695 (+) 1378 Protein_1200 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=811334 P8191_RS05995 WP_002991052.1 1142150..1142836(-) (covR) [Streptococcus pyogenes strain 1044]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=811334 P8191_RS05995 WP_002991052.1 1142150..1142836(-) (covR) [Streptococcus pyogenes strain 1044]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425