Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   RDV59_RS09665 Genome accession   NZ_CP133476
Coordinates   2063407..2064147 (+) Length   246 a.a.
NCBI ID   WP_014634987.1    Uniprot ID   -
Organism   Streptococcus salivarius strain LMG 11489     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2058407..2069147
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RDV59_RS09635 (RDV59_09635) - 2058491..2060758 (+) 2268 WP_038676696.1 Xaa-Pro dipeptidyl-peptidase -
  RDV59_RS09640 (RDV59_09640) - 2060838..2061218 (-) 381 WP_038676698.1 hypothetical protein -
  RDV59_RS09645 (RDV59_09645) - 2061343..2061708 (-) 366 WP_013991116.1 hypothetical protein -
  RDV59_RS09650 (RDV59_09650) - 2061926..2062222 (-) 297 WP_038676700.1 bacteriocin immunity protein -
  RDV59_RS09655 (RDV59_09655) - 2062591..2062983 (-) 393 WP_003094909.1 hypothetical protein -
  RDV59_RS09660 (RDV59_09660) - 2063019..2063153 (-) 135 Protein_1863 Blp family class II bacteriocin -
  RDV59_RS09665 (RDV59_09665) comE/blpR 2063407..2064147 (+) 741 WP_014634987.1 response regulator transcription factor Regulator
  RDV59_RS09670 (RDV59_09670) comD/comD3 2064729..2065478 (+) 750 WP_014634988.1 sensor histidine kinase Regulator
  RDV59_RS09675 (RDV59_09675) - 2065565..2065966 (-) 402 WP_038676702.1 hypothetical protein -
  RDV59_RS09680 (RDV59_09680) - 2066295..2066462 (-) 168 WP_002884432.1 hypothetical protein -
  RDV59_RS09685 (RDV59_09685) - 2066939..2067169 (-) 231 WP_021143664.1 bacteriocin class II family protein -
  RDV59_RS09690 (RDV59_09690) - 2067329..2069074 (-) 1746 WP_038676705.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28677.27 Da        Isoelectric Point: 8.4293

>NTDB_id=799737 RDV59_RS09665 WP_014634987.1 2063407..2064147(+) (comE/blpR) [Streptococcus salivarius strain LMG 11489]
MDIYILEDNLIQQGRLEMVLSQELKKYNKDLSIVHTFDKPQQFIEAIDSTTSNQLFFLDIEIKGEKLKGLDIAKIIREKN
PYATIIFVTTHSEFMPLVFDYQVSALDYIDKSLSEIEFRKKITRALAITMKPLGIENDEIFDFQTQHTAIRIPLNQVIYI
ETSPQKHYVILHGTNNQMTFRANLKDLEKASPSLVSCHRSYLINPNNIIRINKLKREVEMTDGSICPFSRTKAKMLMDTF
KRRNLQ

Nucleotide


Download         Length: 741 bp        

>NTDB_id=799737 RDV59_RS09665 WP_014634987.1 2063407..2064147(+) (comE/blpR) [Streptococcus salivarius strain LMG 11489]
TTGGATATATATATCTTAGAGGACAATCTCATTCAACAAGGACGACTGGAGATGGTATTGTCTCAAGAGTTAAAAAAATA
CAATAAAGACTTATCTATTGTACACACCTTTGATAAGCCTCAGCAATTTATAGAAGCGATTGATTCAACAACTTCTAACC
AGCTCTTTTTTCTTGATATCGAAATTAAGGGAGAAAAATTAAAAGGGCTCGATATTGCTAAAATCATTAGGGAAAAAAAT
CCCTACGCTACTATTATCTTTGTCACTACCCACTCAGAGTTTATGCCACTAGTTTTTGATTACCAAGTATCTGCCCTAGA
CTATATTGATAAAAGTCTCTCTGAAATAGAATTTAGGAAAAAGATAACCAGAGCTTTAGCTATAACTATGAAACCACTTG
GAATAGAGAATGACGAGATTTTTGATTTTCAAACACAACATACAGCTATTCGCATACCTTTAAACCAAGTTATCTATATT
GAAACTTCTCCGCAAAAGCATTATGTGATACTCCATGGTACAAACAATCAAATGACCTTTCGTGCAAATCTAAAGGACCT
TGAAAAAGCTAGTCCTTCACTCGTATCTTGCCATCGTTCGTATCTCATTAACCCTAACAACATTATAAGAATCAACAAAT
TAAAACGTGAAGTCGAAATGACTGATGGTAGTATCTGTCCTTTTTCACGTACCAAAGCTAAAATGCTGATGGATACTTTT
AAAAGAAGGAACCTTCAATGA

Domains

Predicted by InterProScan.

LytTr DNA-binding domain (LytTR)

(150-239)

Response regulator receiver domain (Response_reg)

(18-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

43.59

95.122

0.415
  comE/comE2 Streptococcus equinus JB1

39.241

96.341

0.378
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.2

100

0.378
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.2

100

0.378
  comE/comE1 Streptococcus equinus JB1

38.655

96.748

0.374
  comE Streptococcus pneumoniae TIGR4

35.6

100

0.362
  comE Streptococcus mitis SK321

35.6

100

0.362
  comE Streptococcus mitis NCTC 12261

35.6

100

0.362
  comE Streptococcus infantis strain Atu-4

35.6

100

0.362
  comE Streptococcus pneumoniae Rx1

35.6

100

0.362
  comE Streptococcus pneumoniae D39

35.6

100

0.362
  comE Streptococcus pneumoniae R6

35.6

100

0.362