Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   PWK66_RS00335 Genome accession   NZ_CP118482
Coordinates   53076..53987 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 20160179     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 48076..58987
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PWK66_RS00315 (PWK66_00310) purE 48370..48861 (+) 492 WP_002987716.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  PWK66_RS00320 (PWK66_00315) purK 48848..49921 (+) 1074 WP_002987718.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  PWK66_RS00325 (PWK66_00320) - 49942..51282 (+) 1341 WP_002987721.1 hypothetical protein -
  PWK66_RS00330 (PWK66_00325) purB 51651..52943 (+) 1293 WP_002987723.1 adenylosuccinate lyase -
  PWK66_RS00335 (PWK66_00330) comR 53076..53987 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  PWK66_RS00340 comS 54071..54166 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  PWK66_RS00345 (PWK66_00335) ruvB 54213..55211 (+) 999 WP_002987726.1 Holliday junction branch migration DNA helicase RuvB -
  PWK66_RS00350 (PWK66_00340) - 55349..55786 (+) 438 WP_002987727.1 low molecular weight protein-tyrosine-phosphatase -
  PWK66_RS00355 (PWK66_00345) - 55810..56211 (+) 402 WP_002987730.1 MORN repeat-containing protein -
  PWK66_RS00360 (PWK66_00350) - 56208..57983 (+) 1776 WP_002987732.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=792694 PWK66_RS00335 WP_002986681.1 53076..53987(+) (comR) [Streptococcus pyogenes strain 20160179]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=792694 PWK66_RS00335 WP_002986681.1 53076..53987(+) (comR) [Streptococcus pyogenes strain 20160179]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462