Detailed information NTG0791707

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: PVK51_RS07635
• Genome accession: NZ_CP118310
• Coordinates: 1455341..1456570 (-)
• Length: 409 a.a.
• NCBI ID: WP_002990162.1
• Uniprot ID: Q1JM77
• Organism: Streptococcus pyogenes strain 20154051
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1450341..1461570

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PVK51_RS07615 (PVK51_07570)	rpiA	1450623..1451306 (-)	684	WP_002990155.1	ribose-5-phosphate isomerase RpiA	-
PVK51_RS07620 (PVK51_07575)	-	1451684..1453783 (+)	2100	WP_002990158.1	AAA family ATPase	-
PVK51_RS07625 (PVK51_07580)	-	1453841..1454584 (-)	744	WP_002984942.1	hypothetical protein	-
PVK51_RS07630 (PVK51_07585)	yihA	1454732..1455331 (-)	600	WP_002990160.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
PVK51_RS07635 (PVK51_07590)	clpX	1455341..1456570 (-)	1230	WP_002990162.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
PVK51_RS07640 (PVK51_07595)	-	1456890..1457387 (-)	498	WP_002984955.1	dihydrofolate reductase	-
PVK51_RS07645 (PVK51_07600)	-	1457467..1458306 (-)	840	WP_002990167.1	thymidylate synthase	-
PVK51_RS07650 (PVK51_07605)	-	1458515..1459690 (+)	1176	WP_002990170.1	hydroxymethylglutaryl-CoA synthase	-
PVK51_RS07655 (PVK51_07610)	-	1459677..1460954 (+)	1278	WP_002990172.1	hydroxymethylglutaryl-CoA reductase, degradative	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 45036.57 Da
• Isoelectric Point: 4.6616

>NTDB_id=791707 PVK51_RS07635 WP_002990162.1 1455341..1456570(-) (clpX) [Streptococcus pyogenes strain 20154051]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELSEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLKTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=791707 PVK51_RS07635 WP_002990162.1 1455341..1456570(-) (clpX) [Streptococcus pyogenes strain 20154051]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGTCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTTAAAACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCGATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATTGAAGAAA
CAATGCTTGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

3D structure

• AlphaFold DB: Q1JM77

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.753	100	0.888
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.603	98.044	0.575