Detailed information
Bioinformatically predicted
Overview
| Name | covR | Type | Regulator |
| Locus tag | M0P24_RS01400 | Genome accession | NZ_CP116957 |
| Coordinates | 268941..269633 (+) | Length | 230 a.a. |
| NCBI ID | WP_003066186.1 | Uniprot ID | A0AAW6YHD4 |
| Organism | Streptococcus pasteurianus strain WUSP070 | ||
| Function | repress comR expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 237240..293118 | 268941..269633 | within | 0 |
Gene organization within MGE regions
Location: 237240..293118
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M0P24_RS01190 (M0P24_01190) | - | 237444..240488 (+) | 3045 | WP_069432093.1 | SrtB-anchored collagen-binding adhesin | - |
| M0P24_RS01195 (M0P24_01195) | - | 240724..241050 (+) | 327 | WP_032547211.1 | YdcP family protein | - |
| M0P24_RS01200 (M0P24_01200) | - | 241067..241453 (+) | 387 | WP_054344453.1 | YdcP family protein | - |
| M0P24_RS01205 (M0P24_01205) | - | 241653..242294 (+) | 642 | WP_069432092.1 | CatA-like O-acetyltransferase | - |
| M0P24_RS01210 (M0P24_01210) | - | 242369..243748 (+) | 1380 | WP_069432091.1 | FtsK/SpoIIIE domain-containing protein | - |
| M0P24_RS01215 (M0P24_01215) | - | 243729..244160 (+) | 432 | WP_081338350.1 | hypothetical protein | - |
| M0P24_RS01220 (M0P24_01220) | mobT | 244401..245591 (+) | 1191 | WP_080113547.1 | MobT family relaxase | - |
| M0P24_RS01225 (M0P24_01225) | - | 245607..245747 (+) | 141 | WP_010817889.1 | DUF3789 domain-containing protein | - |
| M0P24_RS01230 (M0P24_01230) | - | 245744..245965 (+) | 222 | WP_010817890.1 | hypothetical protein | - |
| M0P24_RS01235 (M0P24_01235) | - | 246160..246570 (+) | 411 | WP_010817891.1 | ester cyclase | - |
| M0P24_RS01240 (M0P24_01240) | - | 246587..247033 (+) | 447 | WP_010817892.1 | GNAT family N-acetyltransferase | - |
| M0P24_RS01245 (M0P24_01245) | - | 247060..247248 (+) | 189 | WP_010817893.1 | hypothetical protein | - |
| M0P24_RS01250 (M0P24_01250) | - | 247329..247682 (-) | 354 | WP_002576326.1 | helix-turn-helix domain-containing protein | - |
| M0P24_RS11730 | - | 247848..248045 (+) | 198 | WP_009246557.1 | helix-turn-helix domain-containing protein | - |
| M0P24_RS01260 (M0P24_01260) | bcrR | 248035..248649 (+) | 615 | WP_002576325.1 | bacitracin resistance transcriptional activator BcrR | - |
| M0P24_RS01265 (M0P24_01265) | bcrA | 248830..249747 (+) | 918 | WP_002576324.1 | bacitracin ABC transporter ATP-binding protein BcrA | - |
| M0P24_RS01270 (M0P24_01270) | - | 249740..250489 (+) | 750 | WP_002576323.1 | ABC transporter permease | - |
| M0P24_RS01275 (M0P24_01275) | bcrD | 250489..251316 (+) | 828 | WP_010817894.1 | bacitracin resistance undecaprenyl-diphosphatase BcrD | - |
| M0P24_RS01280 (M0P24_01280) | - | 251318..251626 (+) | 309 | WP_010817895.1 | DUF3788 domain-containing protein | - |
| M0P24_RS01285 (M0P24_01285) | - | 251750..251986 (+) | 237 | WP_010817896.1 | hypothetical protein | - |
| M0P24_RS01290 (M0P24_01290) | - | 251961..252458 (+) | 498 | WP_010817897.1 | antirestriction protein ArdA | - |
| M0P24_RS01295 (M0P24_01295) | - | 252476..252979 (+) | 504 | WP_010817898.1 | antirestriction protein ArdA | - |
| M0P24_RS01300 (M0P24_01300) | - | 253090..253479 (+) | 390 | WP_010817899.1 | conjugal transfer protein | - |
| M0P24_RS01305 (M0P24_01305) | - | 253466..255913 (+) | 2448 | WP_010817900.1 | ATP-binding protein | - |
| M0P24_RS01310 (M0P24_01310) | - | 255913..258039 (+) | 2127 | WP_010817901.1 | CD3337/EF1877 family mobilome membrane protein | - |
| M0P24_RS01315 (M0P24_01315) | - | 258036..259043 (+) | 1008 | WP_010817902.1 | lysozyme family protein | - |
| M0P24_RS01320 (M0P24_01320) | - | 259059..259952 (+) | 894 | WP_248497716.1 | conjugal transfer protein | - |
| M0P24_RS01325 (M0P24_01325) | - | 260080..260454 (+) | 375 | WP_010817904.1 | GntR family transcriptional regulator | - |
| M0P24_RS01330 (M0P24_01330) | - | 260456..261313 (+) | 858 | WP_010817905.1 | ABC transporter ATP-binding protein | - |
| M0P24_RS01335 (M0P24_01335) | - | 261316..261957 (+) | 642 | WP_010817906.1 | ABC-2 transporter permease | - |
| M0P24_RS01340 (M0P24_01340) | - | 261975..262361 (+) | 387 | WP_010817907.1 | DUF3592 domain-containing protein | - |
| M0P24_RS01345 (M0P24_01345) | - | 262687..262953 (+) | 267 | WP_236906564.1 | winged helix-turn-helix domain-containing protein | - |
| M0P24_RS01350 (M0P24_01350) | - | 263106..263333 (+) | 228 | Protein_269 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| M0P24_RS01355 (M0P24_01355) | - | 263320..263940 (+) | 621 | WP_010817909.1 | DUF998 domain-containing protein | - |
| M0P24_RS01360 (M0P24_01360) | - | 264149..264391 (+) | 243 | WP_010817910.1 | winged helix-turn-helix domain-containing protein | - |
| M0P24_RS01365 (M0P24_01365) | - | 264431..264793 (-) | 363 | WP_248497717.1 | helix-turn-helix domain-containing protein | - |
| M0P24_RS01370 (M0P24_01370) | - | 264945..265169 (+) | 225 | WP_025189641.1 | hypothetical protein | - |
| M0P24_RS01375 (M0P24_01375) | - | 265189..265554 (+) | 366 | WP_010817913.1 | hypothetical protein | - |
| M0P24_RS01380 (M0P24_01380) | - | 265994..266419 (+) | 426 | WP_010817914.1 | RNA polymerase sigma factor | - |
| M0P24_RS01385 (M0P24_01385) | - | 266409..266654 (+) | 246 | WP_010817915.1 | helix-turn-helix domain-containing protein | - |
| M0P24_RS01390 (M0P24_01390) | - | 267054..267260 (+) | 207 | WP_010817916.1 | excisionase | - |
| M0P24_RS01395 (M0P24_01395) | - | 267340..268536 (+) | 1197 | WP_010817917.1 | tyrosine-type recombinase/integrase | - |
| M0P24_RS01400 (M0P24_01400) | covR | 268941..269633 (+) | 693 | WP_003066186.1 | response regulator transcription factor | Regulator |
| M0P24_RS01405 (M0P24_01405) | - | 269633..271117 (+) | 1485 | WP_003066184.1 | sensor histidine kinase | - |
| M0P24_RS01410 (M0P24_01410) | nrdR | 271307..271801 (+) | 495 | WP_003066183.1 | transcriptional regulator NrdR | - |
| M0P24_RS01415 (M0P24_01415) | - | 271788..272945 (+) | 1158 | WP_003066180.1 | DnaD domain protein | - |
| M0P24_RS01420 (M0P24_01420) | dnaI | 272956..273858 (+) | 903 | WP_013852182.1 | primosomal protein DnaI | - |
| M0P24_RS01425 (M0P24_01425) | der | 274013..275323 (+) | 1311 | WP_003066176.1 | ribosome biogenesis GTPase Der | - |
| M0P24_RS01430 (M0P24_01430) | - | 275467..278556 (+) | 3090 | WP_041973349.1 | DEAD/DEAH box helicase | - |
| M0P24_RS01435 (M0P24_01435) | - | 278814..279410 (+) | 597 | WP_003066174.1 | hypothetical protein | - |
| M0P24_RS01440 (M0P24_01440) | murC | 279444..280775 (+) | 1332 | WP_003066173.1 | UDP-N-acetylmuramate--L-alanine ligase | - |
| M0P24_RS01445 (M0P24_01445) | - | 280827..281321 (+) | 495 | WP_003066172.1 | GNAT family N-acetyltransferase | - |
| M0P24_RS01450 (M0P24_01450) | mltG | 281420..283141 (+) | 1722 | WP_003066171.1 | endolytic transglycosylase MltG | - |
| M0P24_RS01455 (M0P24_01455) | greA | 283224..283706 (+) | 483 | WP_003066170.1 | transcription elongation factor GreA | - |
| M0P24_RS01460 (M0P24_01460) | yidC | 284000..284920 (-) | 921 | WP_003066169.1 | membrane protein insertase YidC | - |
| M0P24_RS01465 (M0P24_01465) | - | 285010..285288 (-) | 279 | WP_003066168.1 | acylphosphatase | - |
| M0P24_RS01470 (M0P24_01470) | - | 285466..286455 (+) | 990 | WP_003066167.1 | LacI family DNA-binding transcriptional regulator | - |
| M0P24_RS01475 (M0P24_01475) | - | 286751..288133 (+) | 1383 | WP_003066166.1 | glycoside hydrolase family 32 protein | - |
| M0P24_RS01480 (M0P24_01480) | - | 288151..289425 (+) | 1275 | WP_003066164.1 | oligosaccharide MFS transporter | - |
| M0P24_RS01485 (M0P24_01485) | - | 289475..290218 (+) | 744 | WP_003066162.1 | TrmH family RNA methyltransferase | - |
| M0P24_RS01490 (M0P24_01490) | - | 290318..290821 (+) | 504 | WP_003066160.1 | HDIG domain-containing metalloprotein | - |
| M0P24_RS01495 (M0P24_01495) | - | 290870..291562 (+) | 693 | WP_003066158.1 | Bax inhibitor-1/YccA family protein | - |
| M0P24_RS01500 (M0P24_01500) | - | 291690..292934 (+) | 1245 | WP_003066153.1 | diaminopimelate decarboxylase | - |
Sequence
Protein
Download Length: 230 a.a. Molecular weight: 26543.50 Da Isoelectric Point: 4.7752
>NTDB_id=781608 M0P24_RS01400 WP_003066186.1 268941..269633(+) (covR) [Streptococcus pasteurianus strain WUSP070]
MSKKILIIEDEKNLARFVSLELQHEGYSVVVETNGRLGLQTALDDDFDLILLDLMLPDMDGFEITRRLRLEKETSIIMMT
ARDSIMDIVAGLDRGADDYIVKPFAIEELLARVRAVFRRQDVEFKREQGNQGKEGLLGLRLNPQNRSAVRGDDEISLTKR
EYDLLSVLLSNVNRVMTREELLANVWRYDTDIETNVVDVYIRYLRGKVDIPGKESYIQTVRGMGYIIREK
MSKKILIIEDEKNLARFVSLELQHEGYSVVVETNGRLGLQTALDDDFDLILLDLMLPDMDGFEITRRLRLEKETSIIMMT
ARDSIMDIVAGLDRGADDYIVKPFAIEELLARVRAVFRRQDVEFKREQGNQGKEGLLGLRLNPQNRSAVRGDDEISLTKR
EYDLLSVLLSNVNRVMTREELLANVWRYDTDIETNVVDVYIRYLRGKVDIPGKESYIQTVRGMGYIIREK
Nucleotide
Download Length: 693 bp
>NTDB_id=781608 M0P24_RS01400 WP_003066186.1 268941..269633(+) (covR) [Streptococcus pasteurianus strain WUSP070]
ATGAGTAAAAAGATTTTAATTATTGAAGATGAAAAAAATCTTGCACGCTTTGTGTCTTTGGAATTACAACATGAAGGTTA
TTCAGTAGTTGTAGAAACAAACGGGCGTTTAGGGCTTCAAACAGCTCTTGATGATGATTTTGACTTGATTTTGCTTGATT
TAATGCTTCCAGATATGGATGGATTTGAAATTACGCGTCGTCTTCGATTGGAAAAAGAAACTTCTATTATTATGATGACA
GCTCGCGACTCTATTATGGATATTGTTGCTGGGCTTGATCGTGGTGCAGACGACTATATTGTCAAACCATTTGCAATTGA
AGAACTCTTGGCTCGTGTTCGTGCCGTTTTTCGTCGGCAAGATGTTGAATTTAAACGAGAACAGGGTAATCAAGGAAAAG
AAGGATTGCTTGGTCTACGCTTAAATCCTCAAAATCGTTCAGCGGTTCGAGGTGATGATGAAATTTCGCTTACAAAACGT
GAGTACGATTTGTTAAGTGTTCTTTTGTCGAATGTTAATCGTGTAATGACACGTGAAGAACTGTTAGCCAATGTTTGGAG
ATATGATACTGATATTGAGACAAATGTTGTTGATGTTTACATTCGTTACCTTCGCGGAAAAGTCGATATTCCAGGTAAAG
AATCTTACATTCAAACAGTTCGTGGAATGGGCTACATTATTCGAGAAAAATAA
ATGAGTAAAAAGATTTTAATTATTGAAGATGAAAAAAATCTTGCACGCTTTGTGTCTTTGGAATTACAACATGAAGGTTA
TTCAGTAGTTGTAGAAACAAACGGGCGTTTAGGGCTTCAAACAGCTCTTGATGATGATTTTGACTTGATTTTGCTTGATT
TAATGCTTCCAGATATGGATGGATTTGAAATTACGCGTCGTCTTCGATTGGAAAAAGAAACTTCTATTATTATGATGACA
GCTCGCGACTCTATTATGGATATTGTTGCTGGGCTTGATCGTGGTGCAGACGACTATATTGTCAAACCATTTGCAATTGA
AGAACTCTTGGCTCGTGTTCGTGCCGTTTTTCGTCGGCAAGATGTTGAATTTAAACGAGAACAGGGTAATCAAGGAAAAG
AAGGATTGCTTGGTCTACGCTTAAATCCTCAAAATCGTTCAGCGGTTCGAGGTGATGATGAAATTTCGCTTACAAAACGT
GAGTACGATTTGTTAAGTGTTCTTTTGTCGAATGTTAATCGTGTAATGACACGTGAAGAACTGTTAGCCAATGTTTGGAG
ATATGATACTGATATTGAGACAAATGTTGTTGATGTTTACATTCGTTACCTTCGCGGAAAAGTCGATATTCCAGGTAAAG
AATCTTACATTCAAACAGTTCGTGGAATGGGCTACATTATTCGAGAAAAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| covR | Streptococcus salivarius strain HSISS4 |
75.217 |
100 |
0.752 |
| covR | Lactococcus lactis subsp. lactis strain DGCC12653 |
63.755 |
99.565 |
0.635 |
| vicR | Streptococcus mutans UA159 |
41.991 |
100 |
0.422 |
| micA | Streptococcus pneumoniae Cp1015 |
41.304 |
100 |
0.413 |