Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   PND17_RS07420 Genome accession   NZ_CP116772
Coordinates   1411307..1411996 (-) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus strain strain TSGB 4141     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1406307..1416996
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PND17_RS07400 (PND17_07400) dnaI 1407114..1408016 (-) 903 WP_002946786.1 primosomal protein DnaI -
  PND17_RS07405 (PND17_07405) - 1408020..1409195 (-) 1176 WP_271298409.1 DnaD domain protein -
  PND17_RS07410 (PND17_07410) nrdR 1409192..1409671 (-) 480 WP_002949642.1 transcriptional regulator NrdR -
  PND17_RS07415 (PND17_07415) covS 1409793..1411310 (-) 1518 WP_002949640.1 HAMP domain-containing sensor histidine kinase Regulator
  PND17_RS07420 (PND17_07420) covR 1411307..1411996 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  PND17_RS07425 (PND17_07425) - 1412152..1412688 (-) 537 WP_002949636.1 DUF177 domain-containing protein -
  PND17_RS07430 (PND17_07430) rsmG 1412985..1413698 (+) 714 WP_271298407.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  PND17_RS07435 (PND17_07435) - 1413768..1415132 (+) 1365 WP_271298531.1 TrkH family potassium uptake protein -
  PND17_RS07440 (PND17_07440) - 1415172..1415843 (+) 672 WP_002946492.1 potassium channel family protein -
  PND17_RS07445 (PND17_07445) - 1415860..1416030 (-) 171 Protein_1452 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=780059 PND17_RS07420 WP_002949638.1 1411307..1411996(-) (covR) [Streptococcus thermophilus strain strain TSGB 4141]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=780059 PND17_RS07420 WP_002949638.1 1411307..1411996(-) (covR) [Streptococcus thermophilus strain strain TSGB 4141]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441