Detailed information NTG0779342

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: POF61_RS00420
• Genome accession: NZ_CP116709
• Coordinates: 64825..65736 (+)
• Length: 303 a.a.
• NCBI ID: WP_000912100.1
• Uniprot ID: A0A0E1EEL0
• Organism: Streptococcus agalactiae strain CNCTC 10/84 sCas9revertant
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 59825..70736

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
POF61_RS00395 (POF61_00395)	purE	60005..60493 (+)	489	WP_001068142.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
POF61_RS00400 (POF61_00400)	purK	60480..61553 (+)	1074	WP_001083997.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
POF61_RS00405 (POF61_00405)	-	61563..61820 (+)	258	WP_000590468.1	hypothetical protein	-
POF61_RS00410 (POF61_00410)	-	62185..63288 (+)	1104	WP_025194614.1	DUF6287 domain-containing protein	-
POF61_RS00415 (POF61_00415)	purB	63374..64672 (+)	1299	WP_000572895.1	adenylosuccinate lyase	-
POF61_RS00420 (POF61_00420)	comR	64825..65736 (+)	912	WP_000912100.1	helix-turn-helix domain-containing protein	Regulator
POF61_RS00425 (POF61_00425)	ruvB	66033..67031 (+)	999	WP_000196633.1	Holliday junction branch migration DNA helicase RuvB	-
POF61_RS00430 (POF61_00430)	-	67183..67620 (+)	438	WP_000754816.1	low molecular weight protein-tyrosine-phosphatase	-
POF61_RS00435 (POF61_00435)	-	67627..68007 (+)	381	WP_000787701.1	hypothetical protein	-
POF61_RS00440 (POF61_00440)	-	68004..69782 (+)	1779	WP_001220911.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35654.11 Da
• Isoelectric Point: 5.6370

>NTDB_id=779342 POF61_RS00420 WP_000912100.1 64825..65736(+) (comR) [Streptococcus agalactiae strain CNCTC 10/84 sCas9revertant]
MLKHFGSKVRNLRVTRNITREDFCGDETELSVRQLARIESGQSIPNLTKAHYIAKQLNVKLDILTGGESLELPKRYKELK
YLILRIPTYADAERLKLRECQFDHIFEEFYDNLPEDECLAIDSLQAKFEVYQTGDINFGVEVLCECFDKVKYKEKYTLND
LIIIDLFLTCAVVSKFNNRAFTKEVFQTICKTLISQNHKLTAEDLFWFNHVLLNCVFVGLCLNSEECLAEMLEVSRQTMV
STHDFHKMPLYFMYQWKYFITIDNDIKSAENAYQQSIMFSKMIDDKHLIKKLELEWQEDITGH

Nucleotide

• Length: 912 bp

>NTDB_id=779342 POF61_RS00420 WP_000912100.1 64825..65736(+) (comR) [Streptococcus agalactiae strain CNCTC 10/84 sCas9revertant]
ATGTTAAAACATTTTGGTAGTAAAGTAAGAAATTTGAGAGTAACTAGAAATATTACTCGCGAAGATTTTTGTGGTGATGA
AACTGAGTTATCTGTAAGACAATTAGCTAGGATTGAAAGTGGACAGTCAATTCCAAACTTGACTAAAGCTCACTACATAG
CTAAACAATTGAATGTAAAATTGGATATTTTAACAGGAGGAGAGAGCTTAGAATTACCTAAACGGTATAAAGAGTTGAAG
TATTTGATTTTAAGAATTCCAACTTATGCAGATGCTGAACGATTAAAATTAAGAGAATGTCAGTTTGATCATATTTTCGA
AGAATTCTATGATAATCTTCCAGAAGACGAGTGCTTAGCAATTGACAGTTTACAAGCTAAATTTGAAGTCTATCAAACAG
GAGACATTAATTTTGGTGTGGAGGTTTTATGCGAATGCTTTGATAAAGTAAAATATAAAGAAAAATATACTCTTAATGAT
TTGATTATCATAGATTTGTTTTTAACTTGTGCAGTTGTATCTAAATTTAACAATAGAGCATTTACTAAAGAAGTATTTCA
AACTATATGTAAAACTTTGATAAGTCAGAACCACAAACTTACAGCAGAAGATTTGTTTTGGTTTAATCATGTACTCCTGA
ATTGTGTATTTGTTGGACTTTGTTTAAATAGTGAAGAGTGTCTTGCAGAAATGTTAGAAGTTAGCCGACAAACGATGGTG
TCAACACATGATTTTCATAAAATGCCTTTATATTTTATGTACCAATGGAAATACTTCATTACAATTGACAATGATATAAA
GTCTGCAGAAAATGCTTACCAACAATCAATTATGTTTTCAAAAATGATTGATGACAAGCATCTAATTAAAAAATTAGAAT
TGGAGTGGCAAGAAGATATAACAGGACATTGA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (10-64)

3D structure

• AlphaFold DB: A0A0E1EEL0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	52.667	99.01	0.521
comR	Streptococcus mutans UA159	44.816	98.68	0.442
comR	Streptococcus pyogenes MGAS8232	42.904	100	0.429
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	44.33	96.04	0.426