Detailed information NTG0771340

Bioinformatically predicted

Overview

• Name: pilR
• Type: Regulator
• Locus tag: PCP57_RS09185
• Genome accession: NZ_CP115287
• Coordinates: 1987916..1989253 (-)
• Length: 445 a.a.
• NCBI ID: WP_003094694.1
• Uniprot ID: A0A0H2ZG94
• Organism: Pseudomonas aeruginosa strain F006
• Function: regulate pilin expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1986132..2008571	1987916..1989253	within	0

Gene organization within MGE regions

Location: 1986132..2008571

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PCP57_RS09175 (PCP57_09185)	-	1986132..1986641 (-)	510	WP_033976381.1	GspH/FimT family pseudopilin	-
PCP57_RS09180 (PCP57_09190)	thiO	1986776..1987870 (+)	1095	WP_039028141.1	glycine oxidase ThiO	-
PCP57_RS09185 (PCP57_09195)	pilR	1987916..1989253 (-)	1338	WP_003094694.1	two-component system response regulator PilR	Regulator
PCP57_RS09190 (PCP57_09200)	pilS	1989268..1990860 (-)	1593	WP_039028118.1	two-component system sensor histidine kinase PilS	Regulator
PCP57_RS09195 (PCP57_09205)	-	1990850..1991095 (-)	246	WP_003102591.1	PP0621 family protein	-
PCP57_RS09200 (PCP57_09210)	-	1991252..1992277 (-)	1026	WP_033972916.1	outer membrane protein assembly factor BamD	-
PCP57_RS09205 (PCP57_09215)	rluD	1992423..1993385 (+)	963	WP_033972915.1	23S rRNA pseudouridine(1911/1915/1917) synthase RluD	-
PCP57_RS09210 (PCP57_09220)	pgeF	1993382..1994110 (+)	729	WP_058179501.1	peptidoglycan editing factor PgeF	-
PCP57_RS09215 (PCP57_09225)	clpB	1994266..1996830 (+)	2565	WP_003094682.1	ATP-dependent chaperone ClpB	-
PCP57_RS09235 (PCP57_09245)	-	1997500..1998011 (-)	512	Protein_1814	IS3 family transposase	-
PCP57_RS29245	-	1998814..1999056 (+)	243	Protein_1815	hypothetical protein	-
PCP57_RS09245 (PCP57_09255)	-	1999415..1999627 (+)	213	WP_328994894.1	fimbrial protein	-
PCP57_RS09250	-	2000266..2000463 (+)	198	WP_071546846.1	hypothetical protein	-
PCP57_RS09255 (PCP57_09260)	-	2000515..2001276 (-)	762	Protein_1818	IS3 family transposase	-
PCP57_RS09260 (PCP57_09265)	-	2001268..2001567 (-)	300	Protein_1819	ESPR domain-containing protein	-
PCP57_RS09265 (PCP57_09270)	-	2001583..2003220 (-)	1638	WP_400638505.1	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-
PCP57_RS09270 (PCP57_09275)	zapE	2003807..2004865 (+)	1059	WP_058018304.1	cell division protein ZapE	-
PCP57_RS09275 (PCP57_09280)	-	2004904..2006211 (-)	1308	WP_328994898.1	NAD(P)/FAD-dependent oxidoreductase	-
PCP57_RS09280 (PCP57_09285)	-	2006275..2006445 (-)	171	WP_003094672.1	DUF3094 family protein	-
PCP57_RS09285 (PCP57_09290)	-	2006471..2006920 (-)	450	WP_033970456.1	MOSC domain-containing protein	-
PCP57_RS09290 (PCP57_09295)	-	2006917..2007546 (-)	630	WP_003094668.1	DUF1780 domain-containing protein	-
PCP57_RS09295 (PCP57_09300)	-	2007679..2008104 (+)	426	WP_033976385.1	GNAT family N-acetyltransferase	-
PCP57_RS09300 (PCP57_09305)	-	2008101..2008571 (+)	471	WP_328994901.1	FAD/FMN-containing dehydrogenase	-

Sequence

Protein

• Length: 445 a.a.
• Molecular weight: 49737.06 Da
• Isoelectric Point: 5.8654

>NTDB_id=771340 PCP57_RS09185 WP_003094694.1 1987916..1989253(-) (pilR) [Pseudomonas aeruginosa strain F006]
MSRQKALIVDDEPDIRELLEITLGRMKLDTRSARNVKEARELLAREPFDLCLTDMRLPDGSGLDLVQYIQQRHPQTPVAM
ITAYGSLDTAIQALKAGAFDFLTKPVDLGRLRELVATALRLRNPEAEEAPVDNRLLGESPPMRALRNQIGKLARSQAPVY
ISGESGSGKELVARLIHEQGPRIERPFVPVNCGAIPSELMESEFFGHKKGSFTGAIEDKQGLFQAASGGTLFLDEVADLP
MAMQVKLLRAIQEKAVRAVGGQQEVAVDVRILCATHKDLAAEVGAGRFRQDLYYRLNVIELRVPPLRERREDIPLLAERI
LKRLAGDTGLPAARLTGDAQEKLKNYRFPGNVRELENMLERAYTLCEDDQIQPHDLRLADAPGASQEGAASLSEIDNLED
YLEDIERKLIMQALEETRWNRTAAAQRLGLTFRSMRYRLKKLGID

Nucleotide

• Length: 1338 bp

>NTDB_id=771340 PCP57_RS09185 WP_003094694.1 1987916..1989253(-) (pilR) [Pseudomonas aeruginosa strain F006]
ATGAGCCGACAAAAAGCCCTGATCGTCGACGATGAACCGGATATCCGCGAGCTGCTGGAAATCACTCTCGGCCGCATGAA
GCTGGACACCCGCAGCGCCCGCAACGTCAAGGAGGCCCGCGAGTTGCTGGCCCGCGAGCCGTTCGACCTGTGCCTCACCG
ACATGCGCCTGCCGGACGGCAGCGGCCTCGATCTGGTCCAGTACATCCAGCAGCGCCATCCACAGACCCCGGTGGCCATG
ATCACCGCGTACGGCAGCCTGGACACCGCGATCCAGGCGCTCAAGGCCGGTGCCTTCGACTTCCTCACCAAACCGGTCGA
CCTCGGTCGCTTGCGGGAGCTGGTGGCAACCGCCCTGCGCCTGCGCAACCCGGAGGCCGAGGAAGCGCCGGTGGACAACC
GCCTGCTCGGCGAATCACCGCCGATGCGCGCCCTGCGCAACCAGATCGGCAAGCTGGCGCGCAGCCAGGCGCCGGTCTAC
ATCAGTGGCGAGTCCGGCAGCGGCAAGGAGCTGGTGGCGCGCCTGATCCATGAGCAGGGGCCACGTATCGAGCGGCCGTT
CGTGCCGGTGAACTGCGGCGCGATTCCCTCCGAACTGATGGAAAGCGAGTTCTTCGGCCACAAGAAAGGCAGCTTCACTG
GCGCTATCGAAGACAAGCAGGGCCTGTTCCAGGCCGCCAGTGGCGGCACCCTGTTCCTCGACGAAGTCGCCGACCTGCCG
ATGGCCATGCAGGTCAAACTGCTCCGAGCGATCCAGGAAAAGGCCGTGCGCGCGGTCGGCGGCCAGCAGGAGGTCGCCGT
CGACGTGCGCATCCTCTGCGCCACCCACAAGGACCTCGCAGCCGAAGTCGGCGCCGGGCGCTTCCGCCAAGACCTCTACT
ACCGCCTCAACGTCATCGAGCTGCGCGTACCGCCGCTGCGCGAACGCCGCGAGGACATCCCGCTGCTCGCCGAACGCATC
CTCAAGCGCCTGGCCGGCGACACCGGCCTGCCGGCCGCCAGACTGACCGGCGACGCACAGGAGAAGCTGAAGAACTACCG
CTTTCCGGGCAACGTCCGCGAGCTGGAAAACATGCTGGAGCGCGCCTACACCCTGTGCGAAGACGACCAGATCCAGCCTC
ACGACCTGCGCCTGGCCGATGCGCCGGGTGCCAGCCAGGAAGGCGCGGCGAGCCTGAGCGAAATCGACAACCTCGAGGAC
TACCTGGAAGACATCGAGCGCAAGCTGATCATGCAGGCACTCGAGGAAACGCGCTGGAACCGCACCGCCGCGGCCCAGCG
CCTGGGCCTGACGTTCCGCTCGATGCGCTACCGCCTGAAAAAGCTGGGCATCGACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (7-115)

• Sigma-54 interaction domain (Sigma54_activat) (135-301)

• Bacterial regulatory protein, Fis family (HTH_8) (402-442)

3D structure

• AlphaFold DB: A0A0H2ZG94

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilR	Pseudomonas aeruginosa PAK	100	100	1
pilR	Acinetobacter baumannii strain A118	51.198	100	0.528
luxO	Vibrio cholerae strain A1552	38.17	100	0.384