Detailed information NTG0763845

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: OIY87_RS10420
• Genome accession: NZ_CP113954
• Coordinates: 2082848..2083576 (-)
• Length: 242 a.a.
• NCBI ID: WP_012962512.1
• Uniprot ID: A0A139R4K2
• Organism: Streptococcus gallolyticus strain XH2168
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2077848..2088576

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OIY87_RS10385 (OIY87_11700)	-	2077916..2078545 (-)	630	WP_009854988.1	thiamine diphosphokinase	-
OIY87_RS10390 (OIY87_11705)	rpe	2078538..2079200 (-)	663	WP_009854989.1	ribulose-phosphate 3-epimerase	-
OIY87_RS10395 (OIY87_11710)	rsgA	2079207..2080079 (-)	873	WP_269724971.1	ribosome small subunit-dependent GTPase A	-
OIY87_RS10410 (OIY87_11725)	-	2081139..2081339 (-)	201	WP_269724972.1	bacteriocin	-
OIY87_RS10415 (OIY87_11730)	comD/comD3	2081471..2082835 (-)	1365	WP_269724973.1	sensor histidine kinase	Regulator
OIY87_RS10420 (OIY87_11735)	comE/comE2	2082848..2083576 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
OIY87_RS10425 (OIY87_11740)	-	2083675..2083968 (-)	294	WP_252521385.1	bacteriocin immunity protein	-
OIY87_RS10430 (OIY87_11745)	-	2084019..2084171 (-)	153	WP_231873055.1	hypothetical protein	-
OIY87_RS10435 (OIY87_11750)	-	2084518..2084829 (-)	312	WP_269724974.1	bacteriocin immunity protein	-
OIY87_RS10440 (OIY87_11755)	-	2084841..2084990 (-)	150	WP_269724975.1	bacteriocin	-
OIY87_RS10445 (OIY87_11760)	-	2085075..2085299 (-)	225	WP_269724976.1	DUF3884 family protein	-
OIY87_RS10450 (OIY87_11765)	-	2085410..2085625 (-)	216	WP_074658217.1	hypothetical protein	-
OIY87_RS10455 (OIY87_11770)	-	2085913..2086050 (+)	138	WP_009854999.1	hypothetical protein	-
OIY87_RS10460 (OIY87_11775)	-	2086072..2087379 (-)	1308	WP_269724977.1	sensor histidine kinase	-
OIY87_RS10465 (OIY87_11780)	comE/comE1	2087387..2088118 (-)	732	WP_269724978.1	response regulator transcription factor	Regulator
OIY87_RS10470 (OIY87_11785)	-	2088135..2088461 (-)	327	WP_009855002.1	LytTR family DNA-binding domain-containing protein	-

Sequence

Protein

• Length: 242 a.a.
• Molecular weight: 28063.45 Da
• Isoelectric Point: 6.7499

>NTDB_id=763845 OIY87_RS10420 WP_012962512.1 2082848..2083576(-) (comE/comE2) [Streptococcus gallolyticus strain XH2168]
MIDIYVLEDDVNQQFRLEKMIDEVLVDNQWQHRCFELFGEPSRLITLIDETVPQIFFLDLDINGDKTKGIEVAKAIRDVS
KTATLVFVTTHSEFMLLTYRAQVSALDFIDKTDSDLAIKENLQACLKKVVEGQVPRLSLDTFIFENNKTKIRIPFEDILY
FETAEAHRLMLVTRTGQRNFYGTIREVKKANHKLFQCHKSYLINPDNVVSLDKKEGLVYFVGGKSCYVSKKHMKELKTKL
ES

Nucleotide

• Length: 729 bp

>NTDB_id=763845 OIY87_RS10420 WP_012962512.1 2082848..2083576(-) (comE/comE2) [Streptococcus gallolyticus strain XH2168]
ATGATTGATATTTATGTTTTGGAAGATGACGTAAATCAGCAGTTTCGCTTGGAAAAAATGATTGACGAGGTGCTTGTGGA
CAATCAGTGGCAACATCGTTGTTTTGAATTGTTTGGTGAGCCTAGTCGTCTTATCACTCTTATTGATGAAACGGTTCCTC
AAATCTTTTTCTTGGATTTGGATATCAATGGCGATAAAACGAAAGGAATTGAAGTTGCCAAGGCGATTAGAGACGTTTCG
AAAACAGCAACACTTGTCTTTGTTACAACGCATTCTGAATTTATGCTCCTGACCTATCGTGCGCAAGTCAGTGCCCTTGA
TTTCATTGATAAAACTGACAGTGACTTGGCAATCAAGGAAAATTTGCAGGCTTGTTTAAAGAAAGTCGTTGAAGGACAAG
TGCCTCGCCTAAGCTTGGATACCTTTATTTTTGAAAACAATAAAACTAAAATCAGAATACCATTTGAAGATATTCTTTAT
TTTGAAACGGCGGAAGCGCACCGTTTGATGTTGGTGACACGGACAGGACAGCGTAATTTTTACGGAACAATTAGAGAAGT
TAAAAAGGCAAATCATAAGCTATTTCAATGCCATAAATCCTATCTGATTAATCCTGATAATGTCGTCAGTTTGGATAAAA
AAGAAGGGCTTGTTTATTTTGTAGGTGGAAAATCTTGCTACGTTTCCAAAAAACACATGAAAGAATTAAAAACTAAACTA
GAAAGTTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (5-113)

3D structure

• AlphaFold DB: A0A139R4K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	70.248	100	0.702
comE/comE1	Streptococcus equinus JB1	43.802	100	0.438
comE/blpR	Streptococcus mutans UA159	42.739	99.587	0.426