Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   OPT59_RS10250 Genome accession   NZ_CP125360
Coordinates   2061431..2062171 (-) Length   246 a.a.
NCBI ID   WP_003061418.1    Uniprot ID   Q8KQN2
Organism   Streptococcus dysgalactiae subsp. equisimilis strain UT_120444     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2056431..2067171
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OPT59_RS10225 (OPT59_10225) - 2056789..2058084 (-) 1296 WP_065359151.1 DNA cytosine methyltransferase -
  OPT59_RS10230 (OPT59_10230) - 2058228..2058500 (-) 273 WP_065957679.1 hypothetical protein -
  OPT59_RS10235 (OPT59_10235) jag 2058811..2059725 (-) 915 WP_015017424.1 RNA-binding cell elongation regulator Jag/EloR -
  OPT59_RS10240 (OPT59_10240) - 2059737..2060564 (-) 828 WP_015017425.1 YidC/Oxa1 family membrane protein insertase -
  OPT59_RS10245 (OPT59_10245) rnpA 2060530..2060889 (-) 360 WP_003056083.1 ribonuclease P protein component -
  OPT59_RS10250 (OPT59_10250) comE/blpR 2061431..2062171 (-) 741 WP_003061418.1 LytTR family DNA-binding domain-containing protein Regulator
  OPT59_RS10255 (OPT59_10255) - 2062175..2063458 (-) 1284 WP_015017426.1 sensor histidine kinase -
  OPT59_RS10260 (OPT59_10260) - 2063459..2064802 (-) 1344 WP_015058070.1 GHKL domain-containing protein -
  OPT59_RS10265 (OPT59_10265) gltX 2065417..2066865 (-) 1449 WP_003053372.1 glutamate--tRNA ligase -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28977.28 Da        Isoelectric Point: 4.8645

>NTDB_id=762540 OPT59_RS10250 WP_003061418.1 2061431..2062171(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain UT_120444]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide


Download         Length: 741 bp        

>NTDB_id=762540 OPT59_RS10250 WP_003061418.1 2061431..2062171(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain UT_120444]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCAATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAGGACATGTTTCTATTTGAGACTCCTCAGACAAGATTGAAACTACCTTACAAAGATATCCTT
TATTTTGCCACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(152-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8KQN2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

47.699

97.154

0.463
  comE/comE1 Streptococcus equinus JB1

42.437

96.748

0.411
  comE/comE2 Streptococcus equinus JB1

40.408

99.593

0.402
  comE/comE2 Streptococcus gordonii strain NCTC7865

39.113

100

0.394
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

39.113

100

0.394