NTDB

Overview

Name	covR	Type	Regulator
Locus tag	OQG81_RS10030	Genome accession	NZ_CP113440
Coordinates	1902849..1903541 (-)	Length	230 a.a.
NCBI ID	WP_014295163.1	Uniprot ID	A0A2G3NPQ1
Organism	Streptococcus macedonicus strain E37
Function	repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 1897849..1908541

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OQG81_RS10010 (OQG81_10005)	dnaI	1898622..1899524 (-)	903	WP_014295159.1	primosomal protein DnaI	-
OQG81_RS10015 (OQG81_10010)	-	1899535..1900695 (-)	1161	WP_058621434.1	DnaD domain protein	-
OQG81_RS10020 (OQG81_10015)	nrdR	1900679..1901176 (-)	498	WP_039671167.1	transcriptional regulator NrdR	-
OQG81_RS10025 (OQG81_10020)	-	1901365..1902780 (-)	1416	WP_257235760.1	HAMP domain-containing histidine kinase	-
OQG81_RS10030 (OQG81_10025)	covR	1902849..1903541 (-)	693	WP_014295163.1	response regulator transcription factor	Regulator
OQG81_RS10035 (OQG81_10030)	-	1903774..1904310 (-)	537	WP_014295164.1	DUF177 domain-containing protein	-
OQG81_RS10040 (OQG81_10035)	htpX	1904435..1905337 (-)	903	WP_014295165.1	zinc metalloprotease HtpX	-
OQG81_RS10045 (OQG81_10040)	-	1905464..1906015 (-)	552	WP_014295166.1	LemA family protein	-
OQG81_RS10050 (OQG81_10045)	rsmG	1906344..1907057 (+)	714	WP_039671169.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
OQG81_RS10055 (OQG81_10050)	-	1907124..1908497 (+)	1374	WP_269441537.1	TrkH family potassium uptake protein	-

Sequence

Protein

Download Length: 230 a.a. Molecular weight: 26458.35 Da Isoelectric Point: 4.8614

                                >NTDB_id=762308 OQG81_RS10030 WP_014295163.1 1902849..1903541(-) (covR) [Streptococcus macedonicus strain E37]

MSKKILIIEDEKNLARFVSLELQHEGYSVVVENNGRLGLQTALDDDFDLILLDLMLPDMDGFEITRRLRLGKETSIIMMT

ARDSIMDVVAGLDRGADDYIVKPFAIEELLARVRAVFRRQDVESKREQDSRGKEGLLGLRLNPQNRSAVRGDDEISLTKR

EYDLLSVLLSNVNRVMTREELLSSVWRYDTDIETNVVDVYIRYLRGKVDIPGKESYIQTVRGMGYIIREK

Nucleotide

Download Length: 693 bp

                                >NTDB_id=762308 OQG81_RS10030 WP_014295163.1 1902849..1903541(-) (covR) [Streptococcus macedonicus strain E37]

ATGAGTAAAAAGATTTTAATTATTGAAGATGAAAAAAATCTTGCACGTTTTGTATCTTTAGAGTTGCAACATGAAGGTTA

TTCAGTAGTAGTAGAAAATAATGGACGACTTGGCCTACAAACAGCTCTAGATGATGATTTTGATTTAATTTTGTTAGACT

TGATGCTTCCAGATATGGATGGTTTTGAAATTACACGCCGTCTTCGATTAGGAAAAGAGACTTCTATTATTATGATGACA

GCTCGTGATTCAATTATGGATGTTGTTGCTGGGCTTGATCGTGGTGCAGATGACTATATTGTTAAACCATTTGCAATTGA

AGAATTGTTAGCTCGTGTCCGTGCTGTTTTTCGTCGTCAAGATGTTGAATCTAAGCGTGAACAAGATAGTCGAGGAAAAG

AAGGGCTACTTGGACTACGCTTAAACCCTCAAAATCGTTCTGCTGTTCGAGGTGATGATGAAATTTCACTTACAAAACGT

GAATATGATTTGCTAAGTGTTCTTTTATCAAATGTTAATCGTGTAATGACACGTGAAGAATTATTGTCTAGTGTTTGGAG

ATATGATACAGATATTGAGACAAATGTTGTTGATGTTTATATCCGTTACCTTCGCGGAAAAGTCGATATTCCAGGTAAAG

AATCTTACATTCAAACAGTTCGTGGAATGGGATACATTATTCGAGAAAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A2G3NPQ1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Streptococcus salivarius strain HSISS4	74.348	100	0.743
covR	Lactococcus lactis subsp. lactis strain DGCC12653	63.755	99.565	0.635
vicR	Streptococcus mutans UA159	42.857	100	0.43
micA	Streptococcus pneumoniae Cp1015	42.174	100	0.422

Detailed information NTG0762308