Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   OS912_RS08880 Genome accession   NZ_CP113266
Coordinates   1739705..1740442 (+) Length   245 a.a.
NCBI ID   WP_061741674.1    Uniprot ID   A0A4J1R4M8
Organism   Streptococcus pneumoniae strain BC1     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1734705..1745442
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OS912_RS08845 (OS912_08850) - 1735637..1735876 (-) 240 WP_001813906.1 hypothetical protein -
  OS912_RS08850 (OS912_08855) - 1736037..1736324 (-) 288 WP_268232903.1 hypothetical protein -
  OS912_RS08855 (OS912_08860) - 1736334..1736744 (-) 411 WP_001278304.1 HIT family protein -
  OS912_RS08860 (OS912_08865) pptA 1736812..1737543 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  OS912_RS08865 (OS912_08870) - 1737540..1738589 (+) 1050 WP_000653771.1 ABC transporter permease -
  OS912_RS08870 (OS912_08875) - 1738757..1739086 (-) 330 WP_000132569.1 hypothetical protein -
  OS912_RS08875 (OS912_08880) - 1739362..1739700 (+) 339 WP_000682124.1 LytTR family DNA-binding domain-containing protein -
  OS912_RS08880 (OS912_08885) comE/blpR 1739705..1740442 (+) 738 WP_061741674.1 response regulator transcription factor Regulator
  OS912_RS08885 (OS912_08890) - 1740456..1741796 (+) 1341 WP_061741673.1 sensor histidine kinase -
  OS912_RS08890 (OS912_08895) blpC 1741840..1741995 (-) 156 WP_000358811.1 quorum-sensing system pheromone BlpC -
  OS912_RS08895 (OS912_08900) - 1742052..1743413 (-) 1362 WP_268232904.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28740.90 Da        Isoelectric Point: 6.2366

>NTDB_id=761443 OS912_RS08880 WP_061741674.1 1739705..1740442(+) (comE/blpR) [Streptococcus pneumoniae strain BC1]
MKIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=761443 OS912_RS08880 WP_061741674.1 1739705..1740442(+) (comE/blpR) [Streptococcus pneumoniae strain BC1]
ATGAAAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1R4M8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.441

100

0.539
  comE/comE1 Streptococcus equinus JB1

43.038

96.735

0.416
  comE/comE2 Streptococcus equinus JB1

38.115

99.592

0.38