Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   OTU47_RS05100 Genome accession   NZ_CP113115
Coordinates   942941..943600 (-) Length   219 a.a.
NCBI ID   WP_000565003.1    Uniprot ID   A0A0E9GWM6
Organism   Streptococcus pneumoniae strain NP2     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 944344..956867 942941..943600 flank 744


Gene organization within MGE regions


Location: 942941..956867
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTU47_RS05100 (OTU47_05100) cclA/cilC 942941..943600 (-) 660 WP_000565003.1 prepilin peptidase Machinery gene
  OTU47_RS05105 (OTU47_05105) - 943670..944116 (+) 447 WP_000155414.1 GNAT family N-acetyltransferase -
  OTU47_RS05110 (OTU47_05110) - 944344..945522 (-) 1179 WP_000175876.1 ROK family transcriptional regulator -
  OTU47_RS05115 (OTU47_05115) - 945802..947064 (+) 1263 WP_000413339.1 PTS sugar transporter subunit IIC -
  OTU47_RS05120 (OTU47_05120) - 947067..947963 (+) 897 WP_050118010.1 PEP phosphonomutase -
  OTU47_RS05125 (OTU47_05125) - 947978..948295 (+) 318 WP_267747168.1 PTS sugar transporter subunit IIB -
  OTU47_RS05130 (OTU47_05130) - 948312..948629 (+) 318 WP_000344534.1 PTS lactose/cellobiose transporter subunit IIA -
  OTU47_RS05135 (OTU47_05135) - 948639..949157 (+) 519 Protein_961 PTS sugar transporter subunit IIC -
  OTU47_RS05140 (OTU47_05140) - 949141..949773 (+) 633 Protein_962 SUMF1/EgtB/PvdO family nonheme iron enzyme -
  OTU47_RS05145 (OTU47_05145) - 949788..950558 (+) 771 WP_000229332.1 sulfite exporter TauE/SafE family protein -
  OTU47_RS05150 (OTU47_05150) - 950836..951081 (-) 246 WP_001867128.1 IS30 family transposase -
  OTU47_RS05155 (OTU47_05155) - 951354..951599 (+) 246 WP_255296208.1 transposase -
  OTU47_RS05160 (OTU47_05160) - 951709..951912 (-) 204 WP_000109957.1 CsbD family protein -
  OTU47_RS05165 (OTU47_05165) - 951943..952551 (-) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  OTU47_RS05170 (OTU47_05170) - 952590..952760 (-) 171 WP_000455066.1 DUF2273 domain-containing protein -
  OTU47_RS05175 (OTU47_05175) amaP 952772..953338 (-) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  OTU47_RS05180 (OTU47_05180) - 953422..953586 (-) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  OTU47_RS05185 (OTU47_05185) mgaSpn 954029..955510 (+) 1482 WP_001205280.1 virulence factor transcriptional regulator MgaSpn -
  OTU47_RS05190 (OTU47_05190) - 955872..956867 (+) 996 WP_000230210.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24841.94 Da        Isoelectric Point: 7.6166

>NTDB_id=760434 OTU47_RS05100 WP_000565003.1 942941..943600(-) (cclA/cilC) [Streptococcus pneumoniae strain NP2]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLSIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSITELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=760434 OTU47_RS05100 WP_000565003.1 942941..943600(-) (cclA/cilC) [Streptococcus pneumoniae strain NP2]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGAGCAT
CTATGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCATAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
AGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E9GWM6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

96.347

100

0.963
  cclA/cilC Streptococcus pneumoniae Rx1

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae D39

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae R6

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

86.758

100

0.868