Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   OTU45_RS11385 Genome accession   NZ_CP113114
Coordinates   2177991..2178698 (+) Length   235 a.a.
NCBI ID   WP_000166472.1    Uniprot ID   A0A0B7LJ86
Organism   Streptococcus pneumoniae strain NP1     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IS/Tn 2176950..2177267 2177991..2178698 flank 724


Gene organization within MGE regions


Location: 2176950..2178698
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTU45_RS11380 (OTU45_11380) - 2177421..2177907 (+) 487 Protein_2210 cupin domain-containing protein -
  OTU45_RS11385 (OTU45_11385) vicR 2177991..2178698 (+) 708 WP_000166472.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 235 a.a.        Molecular weight: 27210.65 Da        Isoelectric Point: 8.0403

>NTDB_id=760379 OTU45_RS11385 WP_000166472.1 2177991..2178698(+) (vicR) [Streptococcus pneumoniae strain NP1]
MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGKQEGDDSDNIADNSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide


Download         Length: 708 bp        

>NTDB_id=760379 OTU45_RS11385 WP_000166472.1 2177991..2178698(+) (vicR) [Streptococcus pneumoniae strain NP1]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTGACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTAACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTACTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAAAACAAGAAGGAGATGATTCAGATAATATCG
CTGACAATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(159-232)

Response regulator receiver domain (Response_reg)

(5-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LJ86

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

48.707

98.723

0.481
  micA Streptococcus pneumoniae Cp1015

47.845

98.723

0.472
  covR Lactococcus lactis subsp. lactis strain DGCC12653

40.773

99.149

0.404
  covR Streptococcus salivarius strain HSISS4

39.744

99.574

0.396