Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   OTU45_RS09465 Genome accession   NZ_CP113114
Coordinates   1861981..1862640 (+) Length   219 a.a.
NCBI ID   WP_000565003.1    Uniprot ID   A0A0E9GWM6
Organism   Streptococcus pneumoniae strain NP1     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1856981..1867640
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTU45_RS09440 (OTU45_09440) - 1857286..1857603 (-) 318 WP_267747168.1 PTS sugar transporter subunit IIB -
  OTU45_RS09445 (OTU45_09445) - 1857618..1858514 (-) 897 WP_050118010.1 PEP phosphonomutase -
  OTU45_RS09450 (OTU45_09450) - 1858517..1859779 (-) 1263 WP_000413339.1 PTS sugar transporter subunit IIC -
  OTU45_RS09455 (OTU45_09455) - 1860059..1861237 (+) 1179 WP_000175876.1 ROK family transcriptional regulator -
  OTU45_RS09460 (OTU45_09460) - 1861465..1861911 (-) 447 WP_000155414.1 GNAT family N-acetyltransferase -
  OTU45_RS09465 (OTU45_09465) cclA/cilC 1861981..1862640 (+) 660 WP_000565003.1 prepilin peptidase Machinery gene
  OTU45_RS09470 (OTU45_09470) - 1862692..1863843 (-) 1152 WP_000481750.1 helix-turn-helix domain-containing protein -
  OTU45_RS09475 (OTU45_09475) - 1863858..1864589 (-) 732 WP_000934017.1 hypothetical protein -
  OTU45_RS09480 (OTU45_09480) - 1864809..1864919 (+) 111 Protein_1884 prepilin peptidase -
  OTU45_RS09485 (OTU45_09485) trpA 1864891..1865667 (-) 777 WP_001127027.1 tryptophan synthase subunit alpha -
  OTU45_RS09490 (OTU45_09490) trpB 1865660..1866883 (-) 1224 WP_000331289.1 tryptophan synthase subunit beta -
  OTU45_RS09495 (OTU45_09495) - 1866861..1867460 (-) 600 WP_000169909.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24841.94 Da        Isoelectric Point: 7.6166

>NTDB_id=760351 OTU45_RS09465 WP_000565003.1 1861981..1862640(+) (cclA/cilC) [Streptococcus pneumoniae strain NP1]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLSIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSITELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=760351 OTU45_RS09465 WP_000565003.1 1861981..1862640(+) (cclA/cilC) [Streptococcus pneumoniae strain NP1]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGAGCAT
CTATGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCATAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
AGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E9GWM6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

96.347

100

0.963
  cclA/cilC Streptococcus pneumoniae Rx1

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae D39

95.89

100

0.959
  cclA/cilC Streptococcus pneumoniae R6

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

86.758

100

0.868