NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	OTU45_RS03040	Genome accession	NZ_CP113114
Coordinates	607464..608201 (+)	Length	245 a.a.
NCBI ID	WP_050116081.1	Uniprot ID	A0A4L7JGD9
Organism	Streptococcus pneumoniae strain NP1
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 602464..613201

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OTU45_RS03010 (OTU45_03010)	-	603784..604071 (-)	288	WP_000777760.1	hypothetical protein	-
OTU45_RS03015 (OTU45_03015)	-	604081..604491 (-)	411	WP_001278301.1	HIT family protein	-
OTU45_RS03020 (OTU45_03020)	pptA	604559..605290 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
OTU45_RS03025 (OTU45_03025)	-	605287..606336 (+)	1050	WP_050116080.1	ABC transporter permease	-
OTU45_RS03030 (OTU45_03030)	-	606533..606844 (-)	312	WP_267750036.1	helicase BlpT	-
OTU45_RS03035 (OTU45_03035)	-	607121..607459 (+)	339	WP_047499348.1	LytTR family DNA-binding domain-containing protein	-
OTU45_RS03040 (OTU45_03040)	comE/blpR	607464..608201 (+)	738	WP_050116081.1	response regulator transcription factor	Regulator
OTU45_RS03045 (OTU45_03045)	-	608215..609555 (+)	1341	WP_001017642.1	sensor histidine kinase	-
OTU45_RS03050 (OTU45_03050)	blpC	609626..609754 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
OTU45_RS03055 (OTU45_03055)	-	609811..611172 (-)	1362	WP_267750037.1	bacteriocin secretion accessory protein	-
OTU45_RS03060 (OTU45_03060)	blpA	611183..612361 (-)	1179	Protein_599	peptide cleavage/export ABC transporter BlpA	-

Sequence

Protein

Download Length: 245 a.a. Molecular weight: 28784.92 Da Isoelectric Point: 6.2361

                                >NTDB_id=760324 OTU45_RS03040 WP_050116081.1 607464..608201(+) (comE/blpR) [Streptococcus pneumoniae strain NP1]

MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGDHQLFFLDIEIRNEEMKGLEVARKIRDRD

PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY

LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA

INNLH

Nucleotide

Download Length: 738 bp

                                >NTDB_id=760324 OTU45_RS03040 WP_050116081.1 607464..608201(+) (comE/blpR) [Streptococcus pneumoniae strain NP1]

ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA

TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGACCATC

AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT

CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA

CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA

GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT

CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA

GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA

AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCT

ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4L7JGD9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38

Detailed information NTG0760324