Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   UKS_RS01800 Genome accession   NZ_AP021887
Coordinates   351676..352422 (+) Length   248 a.a.
NCBI ID   WP_064276246.1    Uniprot ID   A0A178KIL5
Organism   Streptococcus sp. 116-D4     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 346676..357422
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UKS_RS01770 (UKS_03210) - 348113..348400 (-) 288 WP_156011563.1 hypothetical protein -
  UKS_RS01775 (UKS_03220) - 348410..348820 (-) 411 WP_001278317.1 HIT family protein -
  UKS_RS01780 (UKS_03230) pptA 348888..349619 (+) 732 WP_000889954.1 ABC transporter ATP-binding protein Regulator
  UKS_RS01785 (UKS_03240) - 349616..350665 (+) 1050 WP_156011565.1 ABC transporter permease -
  UKS_RS01790 (UKS_03250) - 350728..351057 (-) 330 WP_156011567.1 helicase BlpT -
  UKS_RS01795 (UKS_03260) - 351333..351671 (+) 339 WP_033684769.1 LytTR family DNA-binding domain-containing protein -
  UKS_RS01800 (UKS_03270) comE/blpR 351676..352422 (+) 747 WP_064276246.1 response regulator transcription factor Regulator
  UKS_RS01805 - 352427..353767 (+) 1341 WP_156011569.1 sensor histidine kinase -
  UKS_RS01810 (UKS_03290) blpC 353811..353966 (-) 156 WP_064276248.1 quorum-sensing system pheromone BlpC -
  UKS_RS01815 (UKS_03300) - 354023..355384 (-) 1362 WP_156011571.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 248 a.a.        Molecular weight: 29236.40 Da        Isoelectric Point: 6.0005

>NTDB_id=75340 UKS_RS01800 WP_064276246.1 351676..352422(+) (comE/blpR) [Streptococcus sp. 116-D4]
MRIFVLEDDFSQQARIETTIEKLLKEHHITPSSFEVFGKPDQLLEEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSSKSHHVILYTETDRLEFTASLEEILKQEPRLLQCHRSFLINPANVIHLDKKEKLLFFPNGRSCLIARYKVREVSEA
INNLHLVR

Nucleotide


Download         Length: 747 bp        

>NTDB_id=75340 UKS_RS01800 WP_064276246.1 351676..352422(+) (comE/blpR) [Streptococcus sp. 116-D4]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAAGCTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGAACA
TCATATCACTCCCAGCTCTTTTGAGGTCTTTGGCAAGCCAGACCAACTGCTGGAAGAGGTGCATGAGAAGGGCGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAAGGGCTAGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAATTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGACA
GTAAAAGTCTGGCGGAAGATTGTTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCTTCTAAATCTCATCATGTCATTCTCTATACCGAGACGGACAGACTGGAATTTACAGCGAGTTTAGAGGA
GATTCTCAAGCAGGAGCCTCGTCTCCTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGATACATTTGGATA
AGAAAGAAAAACTCCTTTTCTTCCCCAATGGGAGAAGTTGCCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATCAATAACTTACACTTAGTGAGGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A178KIL5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.144

97.984

0.54
  comE/comE1 Streptococcus equinus JB1

41.772

95.565

0.399
  comE/comE2 Streptococcus equinus JB1

37.603

97.581

0.367

Multiple sequence alignment