NTDB

Overview

Name	dprA	Type	Machinery gene
Locus tag	OGM51_RS21510	Genome accession	NZ_CP107122
Coordinates	4379995..4381119 (-)	Length	374 a.a.
NCBI ID	WP_000228517.1	Uniprot ID	E2QFE2
Organism	Escherichia coli strain S9
Function	ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	4377325..4387077	4379995..4381119	within	0

Gene organization within MGE regions

Location: 4377325..4387077

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OGM51_RS21485 (OGM51_21460)	yrdB	4377325..4377582 (-)	258	WP_001070565.1	DUF1488 domain-containing protein	-
OGM51_RS21490 (OGM51_21465)	aroE	4377579..4378397 (-)	819	WP_000451255.1	shikimate dehydrogenase	-
OGM51_RS21495 (OGM51_21470)	tsaC	4378402..4378974 (-)	573	WP_001296460.1	L-threonylcarbamoyladenylate synthase type 1 TsaC	-
OGM51_RS21500 (OGM51_21475)	yrdD	4378979..4379521 (-)	543	WP_001296461.1	type I DNA topoisomerase	-
OGM51_RS21505 (OGM51_21480)	smg	4379550..4380023 (-)	474	WP_000460673.1	DUF494 family protein Smg	-
OGM51_RS21510 (OGM51_21485)	dprA	4379995..4381119 (-)	1125	WP_000228517.1	DNA-protecting protein DprA	Machinery gene
OGM51_RS21515 (OGM51_21490)	def	4381249..4381758 (+)	510	WP_000114984.1	peptide deformylase	-
OGM51_RS21520 (OGM51_21495)	fmt	4381773..4382720 (+)	948	WP_000004421.1	methionyl-tRNA formyltransferase	-
OGM51_RS21525 (OGM51_21500)	rsmB	4382772..4384061 (+)	1290	WP_000744765.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
OGM51_RS21530 (OGM51_21505)	trkA	4384083..4385459 (+)	1377	WP_000691382.1	Trk system potassium transporter TrkA	-
OGM51_RS21535 (OGM51_21510)	mscL	4385589..4386002 (+)	414	WP_000022450.1	large-conductance mechanosensitive channel protein MscL	-
OGM51_RS21540 (OGM51_21515)	arfA	4385999..4386217 (-)	219	WP_000092695.1	alternative ribosome-rescue factor ArfA	-
OGM51_RS21545 (OGM51_21520)	zntR	4386273..4386698 (-)	426	WP_000285610.1	Zn(2+)-responsive transcriptional regulator	-
OGM51_RS21550 (OGM51_21525)	yhdN	4386709..4387077 (-)	369	WP_000266504.1	DUF1992 domain-containing protein	-

Sequence

Protein

Download Length: 374 a.a. Molecular weight: 40910.86 Da Isoelectric Point: 6.0395

                                >NTDB_id=738171 OGM51_RS21510 WP_000228517.1 4379995..4381119(-) (dprA) [Escherichia coli strain S9]

MVDTEIWLRLMSISSLYGDDMVRIAHWLAKQSHIDAVVLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSE

FYPPQLLATTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLATRGVTITSGLARGIDGVAHKAALQVN

GVSIAVLGNGLNTIHPRRHAPLAASLLEQGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCA

LEQGREVFALPGPIGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQEDVALPFPELLANVGDE

VTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV

Nucleotide

Download Length: 1125 bp

                                >NTDB_id=738171 OGM51_RS21510 WP_000228517.1 4379995..4381119(-) (dprA) [Escherichia coli strain S9]

ATGGTCGATACAGAAATTTGGCTGCGTTTAATGAGCATCAGCAGCTTGTATGGCGATGATATGGTCCGTATAGCTCACTG

GCTGGCAAAACAGTCGCATATTGATGCGGTTGTATTGCAGCAAACAGGGCTTACATTGCGGCAGGCACAACGCTTTCTTT

CATTTCCGCGAAAGAGTATCGAAAGCTCACTTTGTTGGTTGGAGCAACCCAACCATCATTTAATCCCTGCGGACAGCGAA

TTTTATCCTCCTCAACTTCTGGCGACGACAGATTACCCCGGCGCACTGTTTGTTGAAGGAGAACTGCACGCGTTGCATTC

ATTTCAGCTTGCCGTAGTGGGGAGTCGGGCGCATTCATGGTATGGCGAGCGATGGGGACGATTATTTTGCGAAACTCTGG

CGACGCGTGGAGTGACAATTACGAGTGGACTGGCGCGTGGAATCGATGGTGTGGCGCATAAAGCGGCCTTACAGGTAAAT

GGCGTTAGCATTGCTGTATTGGGGAATGGACTTAATACCATTCATCCCCGCCGCCATGCTCCACTGGCTGCCAGTCTACT

TGAGCAAGGTGGTGCTCTCGTCTCGGAATTTCCCCTCGATGTTCCACCCCTTGCTTACAATTTCCCACGAAGAAATCGCA

TTATCAGTGGTCTAAGTAAGGGTGTACTGGTGGTGGAAGCGGCTTTGCGCAGTGGTTCGCTGGTGACAGCACGTTGTGCG

CTTGAGCAGGGGCGTGAAGTTTTTGCTTTGCCAGGTCCAATAGGGAATCCGGGAAGCGAAGGGCCTCACTGGTTAATAAA

ACAAGGTGCGATTCTTGTGACGGAACCGGAAGAAATTCTGGAAAACTTGCAATTTGGATTGCACTGGTTGCCAGACGCCC

CTGAAAATTCATTTTATTCACCAGATCAGGAAGACGTGGCATTGCCATTTCCTGAGCTCCTGGCTAACGTAGGAGATGAG

GTAACACCTGTTGACGTCGTCGCTGAACGTGCCGGCCAACCTGTGCCAGAGGTAGTTACTCAACTACTCGAACTGGAGTT

AGCAGGATGGATCGCAGCTGTACCCGGCGGCTATGTCCGATTGAGGAGGGCATGCCATGTTCGACGTACTAATGTATTTG

TTTGA

Domains

Predicted by InterproScan.

DprA winged helix domain (DprA_WH)

(312-357)

DNA recombination-mediator protein A (DNA_processg_A)

(67-274)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	E2QFE2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
dprA	Vibrio campbellii strain DS40M4	48.78	98.663	0.481
dprA	Vibrio cholerae strain A1552	49.355	82.888	0.409
dprA	Glaesserella parasuis strain SC1401	44.807	90.107	0.404
dprA	Haemophilus influenzae Rd KW20	44.214	90.107	0.398
dprA	Legionella pneumophila strain ERS1305867	44.242	88.235	0.39

Detailed information NTG0738171