Detailed information NTG0072182

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EL334_RS11680
• Genome accession: NZ_AP019192
• Coordinates: 2150998..2151750 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain ASP0581
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2145998..2156750

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL334_RS12695	-	2148431..2150034 (-)	1604	Protein_2148	YhgE/Pip family protein	-
EL334_RS11665 (ASP0581_21550)	-	2150213..2150755 (+)	543	WP_033705079.1	TetR/AcrR family transcriptional regulator	-
EL334_RS11680 (ASP0581_21560)	comE	2150998..2151750 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EL334_RS11685 (ASP0581_21570)	comD/comD1	2151747..2153072 (-)	1326	WP_033705078.1	competence system sensor histidine kinase ComD	Regulator
EL334_RS11690 (ASP0581_21580)	comC/comC1	2153093..2153218 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EL334_RS11700 (ASP0581_21590)	rlmH	2153500..2153979 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL334_RS11705 (ASP0581_21600)	htrA	2154162..2155343 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EL334_RS11710 (ASP0581_21610)	spo0J	2155401..2156159 (+)	759	WP_033705077.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=72182 EL334_RS11680 WP_000866065.1 2150998..2151750(-) (comE) [Streptococcus pneumoniae strain ASP0581]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=72182 EL334_RS11680 WP_000866065.1 2150998..2151750(-) (comE) [Streptococcus pneumoniae strain ASP0581]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGATAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408