Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   EL263_RS02690 Genome accession   NZ_AP018938
Coordinates   497284..498021 (+) Length   245 a.a.
NCBI ID   WP_050221200.1    Uniprot ID   A0AA44S714
Organism   Streptococcus pneumoniae strain ATCC 49619     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 478525..503273 497284..498021 within 0


Gene organization within MGE regions


Location: 478525..503273
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL263_RS02600 (SPAT_0480) - 478525..479805 (+) 1281 WP_001220759.1 restriction endonuclease subunit S -
  EL263_RS02605 (SPAT_0481) psrA 479862..480659 (+) 798 WP_000651177.1 tyrosine-type DNA invertase PsrA -
  EL263_RS02610 (SPAT_0482) - 480670..481275 (+) 606 WP_061710223.1 restriction endonuclease subunit S -
  EL263_RS02615 (SPAT_0483) - 481223..482791 (-) 1569 WP_050103063.1 restriction endonuclease subunit S -
  EL263_RS02620 (SPAT_0484) - 482791..484254 (-) 1464 WP_054387359.1 class I SAM-dependent DNA methyltransferase -
  EL263_RS02625 (SPAT_0485) hsdR 484267..486600 (-) 2334 WP_054387360.1 EcoAI/FtnUII family type I restriction enzme subunit R -
  EL263_RS02635 (SPAT_0486) - 487208..487717 (+) 510 WP_054387361.1 DUF2812 domain-containing protein -
  EL263_RS02640 (SPAT_0487) hrcA 487881..488915 (+) 1035 WP_000255768.1 heat-inducible transcriptional repressor HrcA -
  EL263_RS02645 (SPAT_0488) grpE 488942..489466 (+) 525 WP_000046027.1 nucleotide exchange factor GrpE -
  EL263_RS02650 (SPAT_0489) dnaK 489946..491769 (+) 1824 WP_000034662.1 molecular chaperone DnaK -
  EL263_RS02655 (SPAT_0490) - 491771..492127 (+) 357 WP_000114433.1 hypothetical protein -
  EL263_RS02660 (SPAT_0491) dnaJ 492529..493665 (+) 1137 WP_050073039.1 molecular chaperone DnaJ -
  EL263_RS02665 (SPAT_0492) - 494045..494332 (-) 288 WP_000777760.1 hypothetical protein -
  EL263_RS02670 (SPAT_0493) - 494342..494752 (-) 411 WP_001278301.1 HIT family protein -
  EL263_RS02675 (SPAT_0494) pptA 494820..495551 (+) 732 WP_050221198.1 ABC transporter ATP-binding protein Regulator
  EL263_RS02680 (SPAT_0495) - 495548..496597 (+) 1050 WP_050221199.1 ABC transporter permease -
  EL263_RS02685 (SPAT_0496) - 496659..496988 (-) 330 WP_000132585.1 hypothetical protein -
  EL263_RS02690 (SPAT_0497) comE/blpR 497284..498021 (+) 738 WP_050221200.1 response regulator transcription factor Regulator
  EL263_RS02695 (SPAT_0498) - 498035..499384 (+) 1350 WP_050221201.1 sensor histidine kinase -
  EL263_RS12105 - 499618..499809 (+) 192 WP_376738204.1 hypothetical protein -
  EL263_RS02705 (SPAT_0500) - 500010..500174 (+) 165 WP_049511538.1 hypothetical protein -
  EL263_RS02710 (SPAT_0501) - 500171..500575 (+) 405 WP_050221203.1 hypothetical protein -
  EL263_RS12110 - 500846..501122 (+) 277 Protein_507 immunity protein -
  EL263_RS02725 (SPAT_0503) - 501205..501588 (+) 384 WP_050221205.1 hypothetical protein -
  EL263_RS02730 (SPAT_0504) - 501653..502342 (+) 690 WP_050221206.1 CPBP family intramembrane glutamic endopeptidase -
  EL263_RS02735 (SPAT_0505) blpZ 502384..502632 (+) 249 WP_050221207.1 immunity protein BlpZ -
  EL263_RS02740 (SPAT_0506) - 502662..503273 (+) 612 WP_050221208.1 CPBP family intramembrane glutamic endopeptidase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28828.99 Da        Isoelectric Point: 6.1688

>NTDB_id=71931 EL263_RS02690 WP_050221200.1 497284..498021(+) (comE/blpR) [Streptococcus pneumoniae strain ATCC 49619]
MRIFVLEDDFSQQTRIETTIEKLLKEHQIVPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCMIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=71931 EL263_RS02690 WP_050221200.1 497284..498021(+) (comE/blpR) [Streptococcus pneumoniae strain ATCC 49619]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAAGAACA
TCAGATCGTTCCCAGCTCTTTTGAAGTTTTTGGTAAGCCAGACCAGCTGCTGGCAGAGGTGCATGAGAAGGGAGCTCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAACGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATCCGGGATCGGGAT
CCTTATGCCTTGATAGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCTGCTCTAGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGATA
GTAAAAGTTTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
CTTGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTAGTTCGTTTGGATA
AGAAAGAAAAACTTCTTTACTTTCCCAATGGTGGAAGCTGTATGATAGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT
ATCAATAACTTACATTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.144

99.184

0.547
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

39.669

98.776

0.392
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363

Multiple sequence alignment