Detailed information NTG0071880

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EL271_RS08775
• Genome accession: NZ_AP018937
• Coordinates: 1626410..1627069 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565024.1
• Uniprot ID: A0A4J1XTA1
• Organism: Streptococcus pneumoniae strain HU-OH
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1621410..1632069

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL271_RS08735 (SPOH_1623)	mgaSpn	1621566..1623047 (-)	1482	WP_001205280.1	virulence factor transcriptional regulator MgaSpn	-
EL271_RS08740 (SPOH_1624)	-	1623490..1623654 (+)	165	WP_001808603.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
EL271_RS08745 (SPOH_1625)	amaP	1623738..1624304 (+)	567	WP_000030213.1	alkaline shock response membrane anchor protein AmaP	-
EL271_RS08750 (SPOH_1626)	-	1624316..1624486 (+)	171	WP_000455066.1	DUF2273 domain-containing protein	-
EL271_RS08755 (SPOH_1627)	-	1624525..1625133 (+)	609	WP_000064115.1	Asp23/Gls24 family envelope stress response protein	-
EL271_RS08760 (SPOH_1628)	-	1625164..1625367 (+)	204	WP_000109957.1	CsbD family protein	-
EL271_RS08765	-	1625477..1625716 (-)	240	WP_001005786.1	transposase	-
EL271_RS08770 (SPOH_1629)	-	1625894..1626340 (-)	447	WP_000155432.1	GNAT family N-acetyltransferase	-
EL271_RS08775 (SPOH_1630)	cclA/cilC	1626410..1627069 (+)	660	WP_000565024.1	prepilin peptidase	Machinery gene
EL271_RS08780 (SPOH_1631)	-	1627121..1628272 (-)	1152	WP_000481758.1	XRE family transcriptional regulator	-
EL271_RS08785 (SPOH_1632)	-	1628287..1629018 (-)	732	WP_000934017.1	hypothetical protein	-
EL271_RS08790	-	1629238..1629348 (+)	111	Protein_1648	prepilin peptidase	-
EL271_RS08795 (SPOH_1633)	trpA	1629320..1630096 (-)	777	WP_001127044.1	tryptophan synthase subunit alpha	-
EL271_RS08800 (SPOH_1634)	trpB	1630089..1631312 (-)	1224	WP_000331292.1	tryptophan synthase subunit beta	-
EL271_RS08805 (SPOH_1635)	-	1631290..1631889 (-)	600	WP_000169900.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24951.16 Da
• Isoelectric Point: 8.2409

>NTDB_id=71880 EL271_RS08775 WP_000565024.1 1626410..1627069(+) (cclA/cilC) [Streptococcus pneumoniae strain HU-OH]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILITSSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=71880 EL271_RS08775 WP_000565024.1 1626410..1627069(+) (cclA/cilC) [Streptococcus pneumoniae strain HU-OH]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAACTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A4J1XTA1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae D39	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae R6	95.434	100	0.954
cclA/cilC	Streptococcus mitis SK321	91.324	100	0.913
cclA/cilC	Streptococcus mitis NCTC 12261	85.388	100	0.854