Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   EL277_RS00245 Genome accession   NZ_AP018936
Coordinates   42786..44135 (+) Length   449 a.a.
NCBI ID   WP_000801610.1    Uniprot ID   A0A0X9S2V2
Organism   Streptococcus pneumoniae strain NU83127     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 37786..49135
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL277_RS00220 (SPNU_0039) plsX 37904..38896 (+) 993 WP_000717454.1 phosphate acyltransferase PlsX -
  EL277_RS00225 (SPNU_0040) - 38902..39135 (+) 234 WP_000136449.1 acyl carrier protein -
  EL277_RS00230 (SPNU_0041) - 39172..39471 (+) 300 Protein_35 transposase family protein -
  EL277_RS00235 (SPNU_0042) blpU 39674..39904 (+) 231 WP_001093077.1 bacteriocin-like peptide BlpU -
  EL277_RS12490 (SPNU_0043) - 39907..40032 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  EL277_RS00240 (SPNU_0044) comA 40620..42773 (+) 2154 WP_000668308.1 peptide cleavage/export ABC transporter ComA Regulator
  EL277_RS00245 (SPNU_0045) comB 42786..44135 (+) 1350 WP_000801610.1 competence pheromone export protein ComB Regulator
  EL277_RS00250 (SPNU_0046) purC 44305..45012 (+) 708 WP_000043305.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  EL277_RS00255 (SPNU_0047) - 45069..48794 (+) 3726 WP_000361234.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49567.43 Da        Isoelectric Point: 5.3895

>NTDB_id=71771 EL277_RS00245 WP_000801610.1 42786..44135(+) (comB) [Streptococcus pneumoniae strain NU83127]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=71771 EL277_RS00245 WP_000801610.1 42786..44135(+) (comB) [Streptococcus pneumoniae strain NU83127]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCAAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTTCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
TCTACAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0X9S2V2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae TIGR4

99.555

100

0.996
  comB Streptococcus pneumoniae D39

99.332

100

0.993
  comB Streptococcus pneumoniae R6

99.332

100

0.993
  comB Streptococcus pneumoniae Rx1

99.332

100

0.993
  comB Streptococcus mitis SK321

95.1

100

0.951
  comB Streptococcus mitis NCTC 12261

94.655

100

0.947
  comB Streptococcus gordonii str. Challis substr. CH1

55.556

100

0.557

Multiple sequence alignment