Detailed information NTG0071694

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: D5070_RS10520
• Genome accession: NZ_AP018923
• Coordinates: 2031768..2032811 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JMUB3031
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2026768..2037811

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D5070_RS10490 (JMUB3031_1954)	-	2027196..2028452 (-)	1257	WP_119305751.1	aminopeptidase	-
D5070_RS10495 (JMUB3031_1955)	-	2028455..2028655 (-)	201	WP_000180460.1	DUF1128 family protein	-
D5070_RS10500 (JMUB3031_1956)	-	2028802..2029266 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
D5070_RS10505 (JMUB3031_1957)	-	2029273..2029548 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
D5070_RS10510 (JMUB3031_1958)	-	2029826..2031037 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
D5070_RS10515 (JMUB3031_1959)	vraR	2031149..2031778 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
D5070_RS10520 (JMUB3031_1960)	vraS	2031768..2032811 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
D5070_RS10525 (JMUB3031_1961)	liaF	2032808..2033509 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
D5070_RS10530 (JMUB3031_1962)	-	2033524..2033910 (-)	387	WP_001110179.1	hypothetical protein	-
D5070_RS10535 (JMUB3031_1963)	map	2034127..2034885 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
D5070_RS10545 (JMUB3031_1964)	-	2035416..2036402 (+)	987	WP_000999713.1	FUSC family protein	-
D5070_RS10555 (JMUB3031_1965)	-	2036892..2037305 (-)	414	WP_001837236.1	hypothetical protein	-
D5070_RS10560	-	2037334..2037445 (-)	112	Protein_1952	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=71694 D5070_RS10520 WP_001017131.1 2031768..2032811(-) (vraS) [Staphylococcus aureus strain JMUB3031]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=71694 D5070_RS10520 WP_001017131.1 2031768..2032811(-) (vraS) [Staphylococcus aureus strain JMUB3031]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1