Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   NN994_RS01655 Genome accession   NZ_CP101646
Coordinates   295606..296295 (+) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus strain UCCSt95     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 290606..301295
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NN994_RS01630 (NN994_01630) - 291573..291743 (+) 171 Protein_266 ascorbate 6-phosphate lactonase -
  NN994_RS01635 (NN994_01635) - 291760..292431 (-) 672 WP_064355629.1 potassium channel family protein -
  NN994_RS01640 (NN994_01640) - 292471..293835 (-) 1365 WP_081247984.1 TrkH family potassium uptake protein -
  NN994_RS01645 (NN994_01645) rsmG 293905..294618 (-) 714 WP_064355625.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  NN994_RS01650 (NN994_01650) - 294914..295450 (+) 537 WP_002946488.1 DUF177 domain-containing protein -
  NN994_RS01655 (NN994_01655) covR 295606..296295 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  NN994_RS01660 (NN994_01660) covS 296292..297809 (+) 1518 WP_002949640.1 HAMP domain-containing sensor histidine kinase Regulator
  NN994_RS01665 (NN994_01665) nrdR 297931..298410 (+) 480 WP_011680738.1 transcriptional regulator NrdR -
  NN994_RS01670 (NN994_01670) - 298407..299582 (+) 1176 WP_011680739.1 DnaD domain protein -
  NN994_RS01675 (NN994_01675) dnaI 299586..300488 (+) 903 WP_011680740.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=711200 NN994_RS01655 WP_002949638.1 295606..296295(+) (covR) [Streptococcus thermophilus strain UCCSt95]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=711200 NN994_RS01655 WP_002949638.1 295606..296295(+) (covR) [Streptococcus thermophilus strain UCCSt95]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACTTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441