Detailed information NTG0070467

Bioinformatically predicted

Overview

• Name: uvrB
• Type: Machinery gene
• Locus tag: H7675_RS04240
• Genome accession: NZ_AP023389
• Coordinates: 818262..820253 (+)
• Length: 663 a.a.
• NCBI ID: WP_002989569.1
• Uniprot ID: P0DH39
• Organism: Streptococcus pyogenes strain KUN-0012590
• Function: homologous recombination (predicted from homology) Homologous recombination

Genomic Context

Location: 813262..825253

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7675_RS04220 (KUN2590_07770)	-	813479..814858 (+)	1380	WP_184004956.1	PTS sugar transporter subunit IIC	-
H7675_RS04225 (KUN2590_07780)	-	814855..815007 (+)	153	WP_003062002.1	hypothetical protein	-
H7675_RS04230 (KUN2590_07790)	-	815155..815895 (-)	741	WP_184004960.1	amino acid ABC transporter ATP-binding protein	-
H7675_RS04235 (KUN2590_07800)	-	815895..818069 (-)	2175	WP_063510253.1	ABC transporter substrate-binding protein/permease	-
H7675_RS04240 (KUN2590_07810)	uvrB	818262..820253 (+)	1992	WP_002989569.1	excinuclease ABC subunit UvrB	Machinery gene
H7675_RS04245 (KUN2590_07820)	-	820517..820660 (+)	144	WP_002984200.1	teichoic acid D-Ala incorporation-associated protein DltX	-
H7675_RS04250 (KUN2590_07830)	dltA	820672..822210 (+)	1539	WP_063510252.1	D-alanine--poly(phosphoribitol) ligase subunit DltA	-
H7675_RS04255 (KUN2590_07840)	dltB	822207..823463 (+)	1257	WP_002994626.1	D-alanyl-lipoteichoic acid biosynthesis protein DltB	-
H7675_RS04260 (KUN2590_07850)	dltC	823481..823720 (+)	240	WP_002984216.1	D-alanine--poly(phosphoribitol) ligase subunit DltC	-
H7675_RS04265 (KUN2590_07860)	dltD	823713..824963 (+)	1251	WP_002984219.1	D-alanyl-lipoteichoic acid biosynthesis protein DltD	-

Sequence

Protein

• Length: 663 a.a.
• Molecular weight: 75664.72 Da
• Isoelectric Point: 4.6420

>NTDB_id=70467 H7675_RS04240 WP_002989569.1 818262..820253(+) (uvrB) [Streptococcus pyogenes strain KUN-0012590]
MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYG
EFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYA
DSAVSLRPGQEISRDTLLNQLVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTI
GEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIEMLREMGYTSGVENYSRHMDG
RSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQARKQMLVDYGFRLPSALDNRPLRREEFESHVHQIVYVSAT
PGEYEMSQTNTIIEQIIRPTGLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYM
HSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNVDGHVIMYADK
MTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGLISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEA
AELLDFELAAQMRDLILELKLMD

Nucleotide

• Length: 1992 bp

>NTDB_id=70467 H7675_RS04240 WP_002989569.1 818262..820253(+) (uvrB) [Streptococcus pyogenes strain KUN-0012590]
ATGATTGATAAACGTGATGATAAACCATTTAAACTAAAATCAAAGTATAAACCGTCTGGTGATCAGCCACAAGCTATTGA
AAGCCTAGTTGATAATATCGAGGGCGGAGAAAAAGCTCAGATTCTCCTAGGTGCTACAGGAACGGGAAAAACATACACCA
TGAGCCAAGTAATTAGTAAAGTAAATAAACCTACCTTAGTGATAGCTCACAATAAAACCTTAGCAGGACAATTATATGGT
GAATTTAAAGAATTTTTTCCAGACAATGCTGTGGAATATTTTGTTTCTTATTATGATTACTACCAACCTGAAGCATATGT
CCCATCAAGCGACACCTATATCGAAAAAGATAGTTCAGTCAATGATGAAATCGATAAACTTCGCCATTCAGCCACCTCTT
CTTTACTTGAGCGTAACGATGTCATAGTGGTAGCTTCTGTATCTTGTATTTATGGACTAGGTTCGCCAAAAGAGTACGCA
GATTCAGCAGTCAGCCTACGTCCAGGTCAGGAGATATCACGTGACACTTTGCTAAATCAATTAGTAGATATTCAATTTGA
GCGTAATGATATTGATTTTCAACGCGGCTGTTTTCGTGTACGTGGCGATGTTGTTGAGGTCTTTCCAGCATCCAGGGATG
AACATGCTTTTCGGGTGGAATTTTTCGGGGATGAGATTGACCGTATATGTGAAATCGAAAGTTTAACTGGGAAAACTATT
GGAGAAGTTGACCATTTGGTTTTATTTCCAGCTACTCACTTTGTAACAAATGATGAGCATATGGAGCAATCAATAGCCAA
AATTCAAGCAGAGTTAGCAGAGCAGTTACAGTTATTTGAATCTGAAGGTAAACTACTAGAAGCACAGCGATTACGCCAAA
GAACGGAATATGATATTGAAATGTTACGTGAAATGGGCTATACTAGCGGAGTCGAAAACTATTCCCGTCATATGGATGGC
AGGTCACCAGGAGAACCTCCTTATACCTTGTTAGATTTCTTCCCAGAAGATTTTTTAATTATGATTGATGAAAGTCACAT
GACAATGGGACAAATCAAAGGCATGTATAATGGTGACCAAGCCAGAAAACAAATGCTAGTTGACTATGGTTTTCGATTGC
CATCAGCTCTTGATAATCGTCCCTTAAGACGCGAGGAATTTGAAAGTCATGTGCACCAAATTGTCTATGTTTCAGCAACG
CCTGGTGAATACGAAATGTCACAGACTAATACAATTATTGAGCAAATTATTCGTCCGACTGGGCTACTTGATCCTGAAAT
TGATGTAAGGCCAAGTATGGGGCAAATGGATGATTTGTTGGGAGAAATTAACCAGCGCGTAGCGCGCGATGAACGGACGT
TCATCACAACCTTAACTAAAAAAATGGCAGAAGATTTGACTGATTATCTAAAAGAGATGGGTGTCAAGGTCAAGTATATG
CACAGTGATATTAAAACCTTAGAGCGGACAGAAATTATTCGTGATTTACGACTTGGTGTTTTTGATGTCTTGATTGGAAT
CAATCTGCTCCGTGAAGGGATTGATGTGCCAGAAGTTAGTCTTGTAGCCATTTTGGATGCTGATAAAGAGGGTTTCCTCC
GTAATGAACGCGGCTTGATTCAGACCATCGGTAGAGCAGCTCGAAACGTAGATGGTCATGTCATTATGTATGCGGACAAG
ATGACAGATTCTATGCAGCGGGCTATTGACGAAACGGCTCGTCGTCGTGAGATTCAAATAGCATATAACAAAGCGCACGG
CATCGTTCCACAAACTATAAAAAAAGACATCAGAGGCCTTATTAGTATAAGTAAAACAAGCCACAATGATATATCGAAAG
AAGAGATGGATTATGAAAGTATGTCAAGAGGAGAACGAAAAGAAGCGATCAATGCTCTGCAAAAACAAATGCAAGAGGCA
GCTGAATTACTTGATTTCGAATTGGCAGCTCAAATGCGAGACTTGATTTTAGAACTTAAATTAATGGACTAG

Domains

Predicted by InterProScan.

• Ultra-violet resistance protein B (UvrB) (556-598)

• UvrB interaction domain (UvrB_inter) (164-254)

• Helicase conserved C-terminal domain (Helicase_C) (443-548)

• Type III restriction enzyme, res subunit (ResIII) (17-142)

• UvrB/uvrC motif (UVR) (627-660)

3D structure

• AlphaFold DB: P0DH39

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
uvrB	Streptococcus pneumoniae R6	85.068	100	0.851
uvrB	Streptococcus pneumoniae D39	85.068	100	0.851
uvrB	Streptococcus pneumoniae TIGR4	84.917	100	0.849