Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   MDRSPN_RS02420 Genome accession   NZ_AP018391
Coordinates   455986..456723 (+) Length   245 a.a.
NCBI ID   WP_001219126.1    Uniprot ID   A7XHJ0
Organism   Streptococcus pneumoniae strain MDRSPN001     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 450986..461723
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MDRSPN_RS10825 - 451962..452156 (-) 195 WP_001808905.1 hypothetical protein -
  MDRSPN_RS02390 (MDRSPN_00445) - 452318..452605 (-) 288 WP_000777760.1 hypothetical protein -
  MDRSPN_RS02395 (MDRSPN_00446) - 452615..453025 (-) 411 WP_001278301.1 HIT family protein -
  MDRSPN_RS02400 (MDRSPN_00447) pptA 453093..453824 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  MDRSPN_RS02405 (MDRSPN_00448) - 453821..454870 (+) 1050 WP_000653752.1 ABC transporter permease -
  MDRSPN_RS02410 (MDRSPN_00449) - 455038..455367 (-) 330 WP_000132575.1 hypothetical protein -
  MDRSPN_RS02415 (MDRSPN_00450) - 455643..455981 (+) 339 WP_000682122.1 LytTR family DNA-binding domain-containing protein -
  MDRSPN_RS02420 (MDRSPN_00451) comE/blpR 455986..456723 (+) 738 WP_001219126.1 response regulator transcription factor Regulator
  MDRSPN_RS02425 (MDRSPN_00452) - 456736..458076 (+) 1341 WP_000275284.1 sensor histidine kinase -
  MDRSPN_RS02430 (MDRSPN_00453) - 458316..459662 (-) 1347 WP_001816270.1 IS1380-like element ISSpn5 family transposase -
  MDRSPN_RS02435 - 459822..460001 (+) 180 WP_000538701.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28752.92 Da        Isoelectric Point: 6.2357

>NTDB_id=69303 MDRSPN_RS02420 WP_001219126.1 455986..456723(+) (comE/blpR) [Streptococcus pneumoniae strain MDRSPN001]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=69303 MDRSPN_RS02420 WP_001219126.1 455986..456723(+) (comE/blpR) [Streptococcus pneumoniae strain MDRSPN001]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A7XHJ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384

Multiple sequence alignment