Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   KK0981_RS03915 Genome accession   NZ_AP017971
Coordinates   723838..725172 (+) Length   444 a.a.
NCBI ID   WP_050201384.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain KK0981     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 718838..730172
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KK0981_RS03895 (KK0981_27640) - 719241..719945 (+) 705 WP_000402614.1 DUF6994 family protein -
  KK0981_RS03900 (KK0981_27650) - 719957..720397 (+) 441 WP_000188806.1 ASCH domain-containing protein -
  KK0981_RS03905 (KK0981_27660) - 720519..723065 (+) 2547 WP_001149121.1 M1 family metallopeptidase -
  KK0981_RS03910 (KK0981_27670) ciaR 723174..723848 (+) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  KK0981_RS03915 (KK0981_27680) ciaH 723838..725172 (+) 1335 WP_050201384.1 two-component system sensor histidine kinase CiaH Regulator
  KK0981_RS03920 (KK0981_27690) - 725206..725493 (-) 288 WP_001145225.1 DUF3270 domain-containing protein -
  KK0981_RS03925 (KK0981_27700) - 725633..726562 (+) 930 WP_000411851.1 peptidase U32 family protein -
  KK0981_RS03935 (KK0981_27710) - 726762..729212 (+) 2451 WP_096376114.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50639.37 Da        Isoelectric Point: 9.1661

>NTDB_id=68676 KK0981_RS03915 WP_050201384.1 723838..725172(+) (ciaH) [Streptococcus pneumoniae strain KK0981]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVLNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=68676 KK0981_RS03915 WP_050201384.1 723838..725172(+) (ciaH) [Streptococcus pneumoniae strain KK0981]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTAAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCAGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

99.775

100

0.998
  ciaH Streptococcus pneumoniae D39

99.775

100

0.998
  ciaH Streptococcus pneumoniae R6

99.775

100

0.998
  ciaH Streptococcus pneumoniae TIGR4

99.775

100

0.998
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment