Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   L1A12_RS08245 Genome accession   NZ_CP090882
Coordinates   1629956..1630615 (+) Length   219 a.a.
NCBI ID   WP_000565024.1    Uniprot ID   A0A4J1XTA1
Organism   Streptococcus pneumoniae strain CH2241     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1624956..1635615
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L1A12_RS08205 (L1A12_08205) mgaSpn 1625112..1626593 (-) 1482 WP_001205280.1 virulence factor transcriptional regulator MgaSpn -
  L1A12_RS08210 (L1A12_08210) - 1627036..1627200 (+) 165 WP_001808603.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  L1A12_RS08215 (L1A12_08215) amaP 1627284..1627850 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  L1A12_RS08220 (L1A12_08220) - 1627862..1628032 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  L1A12_RS08225 (L1A12_08225) - 1628071..1628679 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  L1A12_RS08230 (L1A12_08230) - 1628710..1628913 (+) 204 WP_000109957.1 CsbD family protein -
  L1A12_RS08235 (L1A12_08235) - 1629023..1629262 (-) 240 WP_001005783.1 transposase -
  L1A12_RS08240 (L1A12_08240) - 1629440..1629886 (-) 447 WP_000155432.1 GNAT family N-acetyltransferase -
  L1A12_RS08245 (L1A12_08245) cclA/cilC 1629956..1630615 (+) 660 WP_000565024.1 A24 family peptidase Machinery gene
  L1A12_RS08250 (L1A12_08250) - 1630667..1631818 (-) 1152 WP_000481758.1 XRE family transcriptional regulator -
  L1A12_RS08255 (L1A12_08255) - 1631833..1632564 (-) 732 WP_000934017.1 hypothetical protein -
  L1A12_RS08260 (L1A12_08260) - 1632793..1632894 (+) 102 Protein_1648 prepilin peptidase -
  L1A12_RS08265 (L1A12_08265) trpA 1632866..1633642 (-) 777 WP_001127044.1 tryptophan synthase subunit alpha -
  L1A12_RS08270 (L1A12_08270) trpB 1633635..1634858 (-) 1224 WP_000331292.1 tryptophan synthase subunit beta -
  L1A12_RS08275 (L1A12_08275) - 1634836..1635435 (-) 600 WP_000169900.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24951.16 Da        Isoelectric Point: 8.2409

>NTDB_id=645612 L1A12_RS08245 WP_000565024.1 1629956..1630615(+) (cclA/cilC) [Streptococcus pneumoniae strain CH2241]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILITSSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=645612 L1A12_RS08245 WP_000565024.1 1629956..1630615(+) (cclA/cilC) [Streptococcus pneumoniae strain CH2241]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAACTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1XTA1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae Rx1

95.434

100

0.954
  cclA/cilC Streptococcus pneumoniae D39

95.434

100

0.954
  cclA/cilC Streptococcus pneumoniae R6

95.434

100

0.954
  cclA/cilC Streptococcus mitis SK321

91.324

100

0.913
  cclA/cilC Streptococcus mitis NCTC 12261

85.388

100

0.854